注意缺陷多动障碍患儿血清B族维生素水平及其与社会功能的相关性

目的探讨儿童注意缺陷多动障碍(ADHD)与血清B族维生素水平间的关系。方法选取2018年9月至2019年4月来苏州大学附属儿童医院儿童保健科就诊的ADHD患儿103例设为ADHD组,另选取同期在儿童保健科进行健康体检的同年龄段儿童89例设为健康对照组。采用电化学法测定2组儿童血清维生素B1、维生素B2、维生素B6、维生素B9、维生素B12水平。采用Weiss功能缺陷程度评定量表父母版(WFIRS-P)对ADHD患儿各社会功能评分与B族维生素水平进行相关性分析。结果 ADHD组中维生素B9水平(12.55±2.22) nmol/L比(13.26±2.54) nmol/L]和维生素B12水平(278.54±32.00) ng/L比(288.90±31.32) ng/L]均明显低于健康对照组,差异均有统计学意义(t=-2.064、-2.261,均P<0.05)。2组血清维生素B1、维生素B2、维生素B6水平比较,差异均无统计学意义(均P>0.05)。相关性分析显示,仅维生素B12水平与学习/学校维度的社会功能显著负相关(r=-0.208,P=0.035),其余血清B族维生素与各社会功能之间均未发现显著相关性(均P>0.05)。结论 ADHD患儿血清维生素B9和B12水平显著低于健康同龄儿童,血清维生素B12缺乏对ADHD患儿学习/学校维度的社会功能具有影响。儿童期注重B族维生素尤其是维生素B9和B12水平的监测并及时补充,在一定程度上对防治ADHD的发生发展可能有积极意义。

Analysis of serum vitamin B levels and its correlation with social function in children with attention deficit hyperactivity disorder

Objective To analyze the associations between attention deficit hyperactivity disorder(ADHD)and serum vitamin B levels in children.Methods A total of 103 ADHD children who were diagnosed in the Department of Child and Adolescent Healthcare of Children′s Hospital of Soochow University from September 2018 to April 2019 were selected as the ADHD group,and 89 children of the same age who underwent routine physical examinations served as the healthy control group.The serum levels of vitamin B,including vitamin B1,vitamin B2,vitamin B6,vitamin B9,and vitamin B12,were measured by the methods of electrochemistry.Weiss Functional Impairment Rating Scale-Parent Report(WFIRS-P)was applied to analyze the correlation between social function scores and vitamin B levels in ADHD children.ResultsThe levels of vitamin B9(12.55±2.22)nmol/L vs.(13.26±2.54)nmol/L]and vitamin B12(278.54±32.00)ng/L vs.(288.90±31.32)ng/L]in ADHD children were significantly lower than those in healthy children(t=-2.064,-2.261,all P<0.05).No significant difference was observed in serum levels of vitamin B1,vitamin B2 and vitamin B6 between the 2 groups(all P>0.05).Correlation analysis displayed that only vitamin B12 level was significantly and negatively correlated with social function in the learning/school dimension(r=-0.208,P=0.035),and no significant correlation was found between other vitamin B levels and social function(all P>0.05).Conclusions The serum levels of vitamin B9 and B12 in ADHD children were obviously lower than those in healthy children of the same age.Serum vitamin B12 deficiency had an influence on the social function of the learning/school in ADHD children.Attention to the monitoring and timely supplementation of vitamin B in childhood,especially vitamin B9 and B12,may be of positive significance in the prevention of the occurrence and development of ADHD to some extent.