The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration |
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| Authors: | Z Moradi S Azizi R Hobbenaghi |
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| Institution: | 1.Graduated from Faculty of Veterinary Medicine, Urmia University, Urmia, Iran; ;2.Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran; ;3.Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran |
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| Abstract: | A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups (n=20). Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group (P<0.05). Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group (P<0.05). Intraperitoneal administration of CoQ10 (10 mg/kg/day) in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration.Key Words: Ubiquinone (coenzyme Q10), Peripheral nerve regeneration, Crush |
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