| 儿童免疫性血小板减少症发病机制研究进展 |
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| 引用本文： | 谢幸娟,陈振萍.儿童免疫性血小板减少症发病机制研究进展[J].中国实用儿科杂志,2021(2):90-94. |
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| 作者姓名： | 谢幸娟 陈振萍 |
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| 作者单位： | 国家儿童医学中心 |
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| 基金项目： | 国家自然科学基金课题(81970111);北京市自然科学基金课题(7192064);北京市医院管理中心儿科学科协同发展中心专项(XTZD20180205)。 |
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| 摘 要： | 免疫性血小板减少症(immune thrombocytopenia,ITP)是一种由自身免疫介导的出血性疾病,其特点为血小板破坏增多和生成不足。ITP发病机制复杂多样,具有异质性,至今尚未完全明确,在儿童中尤其突出。现有研究表明,免疫失耐受引起各种免疫细胞或分子异常,进而导致血小板破坏增多或生成不足,是ITP的核心发病机制。随着研究的不断深入,越来越多的机制被报道。该文就儿童ITP的发病机制及其研究进展进行介绍。
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| 关 键 词： | 免疫性血小板减少症 发病机制 免疫耐受 血小板 |
Research progress on the pathogenesis of pediatric immune thrombocytopenia |
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| XIE Xing-juan,CHEN Zhen-ping.Research progress on the pathogenesis of pediatric immune thrombocytopenia[J].Chinese Journal of Practical Pediatrics,2021(2):90-94. |
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| Authors: | XIE Xing-juan CHEN Zhen-ping |
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| Institution: | (Hematology Oncology Center,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing Key Laboratory of Pediatric Hematology Oncology,National Key Discipline of Pediatrics(Capital Medical University),Key Laboratory of Major Diseases in Children,Ministry of Education,Beijing 100045,China) |
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| Abstract: | Immune thrombocytopenia(ITP)is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. The pathogenesis of ITP is complex,heterogeneous and remains to be fully elucidated,and it’s especially true in the children. Current researches have shown that the immune intolerance is main reason for the onset of ITP,which leads to the abnormality of immune cells and cytokines,then resulting in increased platelet destruction or decreased platelet production. With the researches deepening,more and more pathogenesis is reported. The article reviews the pathogenesis of ITP and its research progress in recent years. |
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| Keywords: | immune thrombocytopenia pathogenesis immune tolerance platelet |
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