| 多种免疫抑制剂联合治疗儿童重型再生障碍性贫血 |
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| 引用本文： | 谢晓恬,刘振荣.多种免疫抑制剂联合治疗儿童重型再生障碍性贫血[J].临床儿科杂志,1999,17(1):36-39. |
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| 作者姓名： | 谢晓恬 刘振荣 |
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| 作者单位： | 上海铁道大学医学院城泉医院小儿血液科 |
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| 摘 要： | 同时应用环胞菌素，抗胸腺细胞球蛋白，大剂量免疫球蛋白和大剂量甲工泼尼松龙等免疫抑制剂对１７例小儿ＳＡＡ（１０例ＳＡＡ－Ｉ，７例ＳＡＡ－Ⅱ）进行联合免疫抑制治疗。结果３例基本治愈，７例缓 解，３例明显进步，总有效率达７６．５％。（１３／１７例）。
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| 关 键 词： | 再生障碍性贫血 儿童 免疫抑制剂 联合疗法 |
Combined immunosuppressive therapy of childhood severe aplastic anemia with multiple agents |
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| Xie Xiaotian. Liu Zhenrong,Shi Wei,Liu Xingyuan,Yang Jianqian.Combined immunosuppressive therapy of childhood severe aplastic anemia with multiple agents[J].The Journal of Clinical Pediatrics,1999,17(1):36-39. |
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| Authors: | Xie Xiaotian Liu Zhenrong Shi Wei Liu Xingyuan Yang Jianqian |
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| Institution: | Xie Xiaotian. Liu Zhenrong,Shi Wei,Liu Xingyuan,Yang Jianqian. Department of Pediatric Hematology I Oncology,Gan-quan Hospital affiliated to Medical School of Shanghai Railway University,Shanghai 200065 |
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| Abstract: | Combined immunosuppressive (IS) therapy were undertaken in 17 cases of childhood severe aplastic anemia (SAA)(10 cases SAA-I and 7 cases SAA-IDwith cyclosporin A(CSA), antithymocyte globulin (ATG). high-dose im-munoglobulin (HDIG) and high-dose methylprednisolone (HDMP). The results showed that there was a response rate o{ 76- 5%(13/17) including cure on 3 cases, complete response on 7 cases (CR)and partial response (PR) on 3 cases, respectively. Eight of 10 cases (80%) with acute SAA (SAA-I) were well response to the combined therapy. It is confirmed that the response rate and response grade in the patients treated by multiple IS agents were significantly higher than that by single IS agents reported previously. No severe side-effects were observed during combined IS therapy. |
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| Keywords: | aplastic anemia Cyclosporin A antithymocyte globulin high-dose immunoglobulin |
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