动脉粥样硬化斑块稳定性的影响因素分析

目的 探讨动脉粥样硬化斑块稳定性及其影响因素.方法 回顾性分析30例经外科手术病理检查证实为周围血管动脉粥样硬化患者的病理资料,根据斑块类型分为稳定性斑块组及不稳定性斑块组,比较两组的相关临床因素;采用单因素分析方法,分析动脉粥样硬化斑块稳定性与临床因素的相关性.结果 血浆纤维蛋白原（FIB）、低密度脂蛋白（LDL）、脉压差及既往心脑血管疾病史在两组间有差异,不稳定性斑块组患者的FIB、LDL水平较稳定性斑块组患者高,既往有心脑血管疾病史的患者也较稳定性斑块组为多,且差异有统计学意义（P＜0.05）.结论 FIB、LDL、脉压差及既往心脑血管疾病史是动脉粥样硬化不稳定性斑块的影响因子.

Influence factors for atherosclerotic plaque stability

Objective To discuss the influence factors for atherosclerotic plaque stability.Methods The pathological data of 30 cases with peripheral vascular atherosclerosis confirmed by pathological study after surgery were retrospectively collected;the 30 cases were,according to the type of plaques,divided into stable plaque group and unstable plaque group;a comparative study was made to the related clinical factors between the 2 groups; single factor analysis method was applied to analyze the correlation between atherosclerotic plaque stability and the clinical factors.Results There existed a difference in FIB,LDL,pulse pressure difference and the past history of cardio-cerebrovascular disease between the 2 groups ;the levels of FIB and LDL of the cases in unstable plaque group were higher than those of the cases in stable plaque group,and there were more cases with the past history of cardio-cerebrovascular disease in unstable plaque group than those in stable plaque group,the difference was of statistical significance （P ＜ 0.05）.Conclusions FIB,LDL,pulse pressure difference and the past history of cardio-cerebrovascular disease are the influence factors for atherosclerotic plaque unstability.