乙酰唑胺负荷MR灌注成像对脑血管储备功能的评估

目的探讨乙酰唑胺(ACZ)负荷MR灌注成像对评估脑血管储备功能的价值。方法运用磁共振灌注成像(perfusion-weighted imaging,PWI)对7例脑梗死患者口服ACZ前后分别进行对比剂首过期成像,分析PWI所得参数,包括脑血容量(regionalcerebral blood volume,rCBV)及血流平均通过时间(regional mean transit time,rMTT),以此评估脑血管储备功能(cerebrovascular re-serve capacity,CRC)。结果7例患者口服ACZ前后的rMTT图均发现视觉异常区,仅5例患者有rCBV异常区,并且rMTT异常的区域大于rCBV异常区;口服ACZ后rMTT图和rCBV图的异常区要小于口服ACZ前;rMTT异常区为rMTT延长,rCBV异常区则包括rCBV增加和rCBV减少2类。结论ACZ负荷磁共振PWI在脑血管储备功能研究中有重要价值。

Preliminary Study of Cerebrovascular Capacity with MR Perfusion- Weighted Imaging after Administration of Acetazolamide

Objective To study the value of MR perfusion-weighted imaging(PWI)after administration of acetazolamide(ACZ)in evaluating the cerebrovascular capacity.Methods MR perfusion-weighted imaging were performed before and after ACZ administeredorally in 7 cases with cerebral infarction.The values of rCBV and rMTT were analysed and the cerebrovascular capacity were evaluated.Results The prolonged rMTT was found in rMTT map before and after ACZ in all cases.Only 5 subjects were abnormal at rCBV map visually.rMTT was increased at the abnormal region on rMTT map.The abnormal regions at rCBV maps included both rCBV increased or decreased.The abnormal region was larger at rMTT map than that at rCBV map.Conclusion MR perfusion-weighted imaging with ACZ test has significant value in assessing the cerebrovascular capacity.