糖尿病视网膜病变内皮细胞受损与凝血功能异常的相关性研究

目的 研究糖尿病视网膜病变( diabetic retinopathy,DR)内皮细胞受损与凝血功能异常的相关性.方法选择糖尿病患者89例,按眼底荧光造影结果分为眼底正常组(NDR组,n=30)、背景期视网膜病变组(BDR组,n=32)和增殖期视网膜病变组(PDR组,n=27)；同时选取32例健康志愿者作为正常对照组;...

Correlation of endothelial cell damage and abnormal coagulation in Diabetic retinopathy

Objective To analyze the correlation of endothelial cell damage and abnormal coagulation in Diabetic retinopathy.Methods A total of 89 diabetes were enrolled.According to fluorescein angiography,all subjects were divided into normal（NDR,n=30）,background retinopathy（BDR,n=32） and proliferative retinopathy（PDR,n=27）;32 healthy controls came from healthy volunteers.The levels of plasma von Willebrand factor（vWF） and lipoprotein（a） were measured by ELISA and compared in different groups.Results ①The levels of vWF and lipoprotein（a） were elevated in patients with diabetes compared with control subjects,and these indicators were increased gradually with the deterioration of retinopathy（P0.01）.② Plasma levels of vWF were related to concentrations of HbA1c,FPG,CHO,TG,fibrinogen and duration of disease（r value equals to 0.568,0.348,0.589,0.307,0.873 and 0.327 respectively,P0.01）.③ Serum levels of Lp（a） were related to concentrations of vWF,CHO,LDL-C,fibrinogen and duration of disease（r value equals to 0.669,0.561,0.392,0.555 and 0.277 respectively,P0.01）.Conclusion ①vWF and Lp（a） concentrations are closely related to the severity of diabetic retinopathy,and these two non-invasive indicators may be considered as a predictor of diabetes microvascular complications.②Endothelial cell injury and coagulation abnormalities may be involved in the progression of diabetic retinopathy.