| 他克莫司对三硝基苯磺酸诱导大鼠肠炎模型的治疗作用 |
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| 引用本文： | 田力,曹悦鞍,夏菁,彭朝胜,张文洛,谢文秀,杨璐.他克莫司对三硝基苯磺酸诱导大鼠肠炎模型的治疗作用[J].海军总医院学报,2011,0(3):129-132. |
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| 作者姓名： | 田力 曹悦鞍 夏菁 彭朝胜 张文洛 谢文秀 杨璐 |
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| 作者单位： | 海军总医院特需医疗部,北京,100048 |
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| 摘 要： | 目的 观察他克莫司对炎症性肠炎模型大鼠的作用及对肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-8的影响.方法将30只雄性大鼠随机分为正常对照组、肠炎模型组、实验组,每组10只.用三硝基苯磺酸(2,4,6-trinitrobenzene sulfonic acid,TNBS)灌肠诱导建立大鼠结肠炎急性...
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| 关 键 词： | 他克莫司 结肠炎 肿瘤坏死因子-α 白介素-6 白介素-8 髓过氧化物酶 |
Effects of tacrolimus on trinitrobenzene sulfonic acid-induced colitis |
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| TIAN Li,CAO Yue-an,XIA Jing,PENG Chao-sheng,ZHANG Wen-luo,XIE Wen-xiu,YANG Lu.Effects of tacrolimus on trinitrobenzene sulfonic acid-induced colitis[J].Journal of Naval General Hospital of PLA,2011,0(3):129-132. |
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| Authors: | TIAN Li CAO Yue-an XIA Jing PENG Chao-sheng ZHANG Wen-luo XIE Wen-xiu YANG Lu |
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| Institution: | TIAN Li,CAO Yue-an,XIA Jing,PENG Chao-sheng,ZHANG Wen-luo,XIE Wen-xiu,YANG Lu(Department of the Special Care Medical Center,Naval General Hospital,Beijing 100048,China) |
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| Abstract: | Objective To investigate Tacrolimus effects on Intestinal Damage and Inflammatory cytokines of rats with trinitrobenzene sulfonic acid-induced colitis.Methods Thirty male Sprague-Dawley(SD) rats were randomly divided into three groups: normal control group,TNBS induced colitis group and treatment group.A solution containing 2,4,6-trinitrobenzene sulfonic acid(TNBS) was instilled into the distal colon in the rat(at a dose of 100 mg/kg) to set up colitis rat model.The rats in treatment group were treated with... |
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| Keywords: | Tacrolimus Colitis Tumor necrosis factor-alpha Interleukin-6 Interleukin-8 Myeloperoxidase |
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