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| 鼻咽癌组织~(18)F-FDG摄取与Glut-1和VEGF表达关系研究 | |
| 引用本文： | 石卫民,范义湘,黎静,尹吉林.鼻咽癌组织~(18)F-FDG摄取与Glut-1和VEGF表达关系研究[J].中国医学影像学杂志,2010,18(3):281-284. |
| 作者姓名： | 石卫民 范义湘 黎静 尹吉林 |
| 作者单位： | 1. 广东省第二人民医院肿瘤一科,广东广州,510010 2. 广州军区总医院肿瘤科 3. 广州军区总医院核医学科 |
| 摘 要： | 目的: 探讨鼻咽癌的18F-FDG摄取与肿瘤组织葡萄糖易化扩散转运蛋白及血管内皮细胞生长因子表达的关系.材料和方法:对40例鼻咽癌患者进行正电子发射体层显像(PET)检查,测定肿瘤最大摄取值(SUVmax);应用标准链霉菌抗生物素蛋白-过氧化物酶亲和(SP)免疫组化法检测40例患者肿瘤组织葡萄糖易化扩散转运蛋白1(Glut-1)和血管内皮细胞生长因子(VEGF)的表达.结果:40例鼻咽癌组织的SUVmax为9.45±1.87;40例鼻咽癌组织Glut-1阳性细胞率为45.18%,VEGF染色阳性细胞率为60.8%;鼻咽癌组织18F-FDG摄取(SUVmax)与Glut-1表达阳性率分级相关(r=0.369,P=0.019),鼻咽癌组织18F-FDG摄取(SUVmax)与VEGF表达阳性率分级相关(r=0.460,P=0.03).结论:鼻咽癌组织18F-FDG摄取与Glut-1和VEGF过度表达相关. |
| 关 键 词： | 鼻咽肿瘤 放射性示踪剂 正电子发射断层显像术 葡萄糖转运蛋白质类 易化性 血管内皮生长因子类 |
Relationship Between Fluorine-18 Fluorodeoxyglucose Uptake and Expression of Glut-1 and VEGF in Nasophygeal Carcinoma |
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| Shi,Weiming Fan,Yixiang Li,Jing Yin,Jilin.Relationship Between Fluorine-18 Fluorodeoxyglucose Uptake and Expression of Glut-1 and VEGF in Nasophygeal Carcinoma[J].Chinese Journal of Medical Imaging,2010,18(3):281-284. | |
| Authors: | Shi Weiming Fan Yixiang Li Jing Yin Jilin |
| Institution: | Shi,Weiming Fan,Yixiang Li,Jing Yin,Jilin Department of Oncology,Guangdong NO.2 Provincial People\'s Hospital,Guangzhou,Guangdong 510010 |
| Abstract: | Objiective To assess the relationship between the overexpression of facilitative glucose transporter(Glut-1) and vascular endothelial growth factor(VEGF)and fluorine-18 fluorodeoxyglucose(18F-FDG) uptake of nasophageal carcinoma.Materials and methods From March 2005 to October 2006,40 patients with nasophageal carcinoma were imaged with 18F-FDG positron emission tomography(PET).Their maximum standard uptake value(SUVmax) were measured.Tumor specimens of all cases were studied in paraffin sections for SP imm... |
| Keywords: | nasopharyngeal neoplasms radioactive tracers positron-emission tomography glucose transport proteins facilitative vascular endothelial growth factors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |