参麦注射液对结直肠癌化疗患者免疫功能的影响

 目的 探讨参麦注射液对结直肠癌化疗患者免疫功能的影响。方法 选取2017-03至2018-02青海省人民医院收治的结直肠癌化疗患者88例,随机分为研究组和对照组,每组44例。全部患者采用XELOX化疗方案治疗,对照组采用脾多肽治疗,研究组在对照组基础上,采用参麦注射液治疗,根据RECIST实体瘤疗效标准评估两组的疗效。检测两组治疗前后的血清CD3⁺、CD4⁺、CD4⁺/CD8⁺、NK细胞。采用卡氏评分(KPS)评估两组的生存质量,记录两组的不良反应发生情况。结果 两组的缓解率对比,研究组为43.18%,对照组为36.36%,差异无统计学意义(P>0.05)。两组的有效率对比,研究组(84.09%)高于对照组(65.09%),差异有统计学意义(P<0.05)。研究组治疗后的CD3⁺、CD4⁺、CD4⁺/CD8⁺、NK细胞明显升高,且高于对照组治疗后的水平,差异有统计学意义(P<0.05)。研究组的生存质量改善程度(36.36%)优于对照组(27.27%),差异有统计学意义(P<0.05)。研究组的恶心呕吐、白细胞减少、肝损伤、神经毒性发生率均低于对照组,差异有统计学意义(P<0.05)。结论 参麦注射液能进一步提高结直肠癌化疗的疗效,改善免疫功能及生存质量。

Effect of Shenmai injection combined with spleen polypeptide on immune function in patients with colorectal cancer undergoing chemotherapy

Objective To investigate the effect of Shenmai injection combined with spleen polypeptide on immune function in patients with colorectal cancer undergoing chemotherapy.Methods Eighty-eight patients with colorectal cancer were divided into the study group and the control group. All these patients underwent XELOX chemotherapy. The control group was treated with spleen polypeptide while the study group was additionally treated with Shenmai injection. The efficacy of the two groups was evaluated according to the efficacy criteria of RECIST solid tumors. Serum CD3⁺, CD4⁺, CD4⁺/CD8⁺ and NK cells were detected in the two groups before and after treatment. The quality of life of patients in the two groups was assessed by KPS. The incidence of adverse reactions in the two groups was recorded.Results The difference in the remission rate was not statistically significant between the two groups (P>0.05). The effective rate of the study group was higher than that of the control group. The difference was statistically significant (P<0.05). The levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ and NK cells in the study group were significantly higher than those in the control group after treatment. The difference was statistically significant (P<0.05). The quality of life was improved more significantly in the study group than in the control group. The difference was statistically significant (P<0.05). The incidence of nausea and vomiting, leukocyte reduction, liver injury and neurotoxicity in the study group was lower than that in the control group. The difference was of statistical significance (P<0.05).Conclusion Shenmai injection can enhance the curative effect of colorectal cancer chemotherapy while improving the immune function and quality of life of patients.