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| 不同剂量红景天苷在大鼠体内的药动学研究 | |
| 引用本文： | 刘晓晖,张莉,胡建华,陈莉.不同剂量红景天苷在大鼠体内的药动学研究[J].武警医学,2011,22(3):231-233,236. |
| 作者姓名： | 刘晓晖 张莉 胡建华 陈莉 |
| 作者单位： | 1. 330001,南昌,武警江西总队医院检验科;300162,天津,武警医学院药剂学教研室 2. 武警医学院药剂学教研室,天津,300162 3. 武警江西总队医院检验科,南昌,330001 |
| 摘 要： | 目的研究不同剂量红景天苷在大鼠体内的药动学。方法采用RP—HPLC内标法测定大鼠尾静脉注射不同剂量红景天苷（15、30、60mg／kg）后血清中的药物浓度。比较不同给药剂量下，红景天苷的血药浓度-时间曲线图及其经3P97程序处理所得的药动学参数。结果根据药动学房室模型的判断方法，初步判定大鼠静脉注射后红景天苷在体内的过程符合二室模型。在低、中、高给药剂量下红景天苷的分布半衰期（T1/2a）分别为4．96、2．01和4．36min，消除半衰期（T1/2a）分别为24．24、19．40和16．88min。C0、AUC0-t和AUC0-∞随着剂量的增加均呈线性增加，其中AUC0-1和AUC0-∞分别为362．15、879．77、1421．48（ug·min）／ml和383．09、884．52、1426．63（ug·min）／ml。结论红景天苷给药剂量在15—60mg／kg范围内，其药动学行为呈线性关系，未显现出药动学差异。 |
| 关 键 词： | 红景天苷 药物动力学 剂量 静脉注射 HPLC |
A study of pharmacokinetics of salidroside in rats at different doses |
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| LIU Xiaohui,ZHANG Li,HU Jianhua,CHEN Li.A study of pharmacokinetics of salidroside in rats at different doses[J].Medical Journal of the Chinese People's Armed Police Forces,2011,22(3):231-233,236. | |
| Authors: | LIU Xiaohui ZHANG Li HU Jianhua CHEN Li |
| Institution: | LIU Xiaohui~(1,2),ZHANG Li~2,HU Jianhua~2,and CHEN Li~1.1.Department of Clinical Laboratory,Jiangxi Provincial Corps Hospital of Chinese People's Armed Police Forces,Nanchang 330001,China,2.Department of Pharmaceutics,Medical College of Chinese People's Armed Police Forces,Tianjin 300162 |
| Abstract: | Objective To study the kinetic parameters of salidroside in rats after intravenous administration of different doses of salidroside.Methods The serum concentration of salidroside was analyzed by reversed - phase high - performance liquid chroma-tography (RP - HPLC)and the pharmacokinetic parameters were calculated by 3P97 following a single intravenous administration of salidroside at doses of 15,30,60 mg/kg in rats.Results The concentration - time data showed the characteristics of a two - compartment mode... |
| Keywords: | HPLC |
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