| HPLC法测定畅中胶囊中厚朴酚与和厚朴酚的含量 |
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| 引用本文： | 郭迎霞,刘艳丽,郭红艳.HPLC法测定畅中胶囊中厚朴酚与和厚朴酚的含量[J].解放军药学学报,2008,24(3):264-266. |
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| 作者姓名： | 郭迎霞 刘艳丽 郭红艳 |
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| 作者单位： | 1. 河北省邯郸市药品检验所
2. 邯郸市中医院,河北,邯郸,056001 |
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| 摘 要： | 目的建立用反相高效液相色谱法同时测定畅中胶囊中厚朴酚与和厚朴酚含量的方法。方法以乙睛-水-冰醋酸（60：38：2）为流动相，SHIMADZU VP-ODS（250mm×4．6mm，5μm）为固定相；检测波长为294nm；流速：1．0ml／min。结果厚朴酚在0．2008～5．02μg的浓度范围内线性关系良好，r=0．9999（n=5），平均回收率为99．5％，RSD为0．5％；和厚朴酚在0．1202～3．005μg的浓度范围内线性关系良好，r=0．9999（n=5），平均回收率为99．4％，RSD为0．5％。结论该法结果准确、方法简便、分离度高可作为该制剂质量标准的内容。
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| 关 键 词： | HPLC 畅中胶囊 厚朴酚 和厚朴酚 |
| 文章编号： | 1008-9926(2008)03-0264-03 |
| 修稿时间： | 2008年1月8日 |
Determination of Magnolol and Honokiol in the Changzhong Capsules by HPLC |
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| GUO Ying-Xia,LIU Yan-Li,GUO Hong-Yan.Determination of Magnolol and Honokiol in the Changzhong Capsules by HPLC[J].Pharmaceutical Journal of Chinese People's Liberation Army,2008,24(3):264-266. |
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| Authors: | GUO Ying-Xia LIU Yan-Li GUO Hong-Yan |
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| Institution: | GUO Ying-Xia, LIU Yan-Li, GUO Hong-Yan (2Institute for Drug Control of Handan,3TCM Hospital of Handan,Handan 056001 ,Hebei China) |
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| Abstract: | Aim To establish a method for simultaneous determination of magnolol and honokiol in the Changzhong Capsules. Methods On SHIMADZU VP-ODS column （4.6mm × 250mm ,5μm） ;with acetonitrile-water-acetic acid （60：38： 2） as the mobile and UV determination at 294nm. Results A good linearity was obtained over the range of 0.200 8 -5. 02μg for magnolol and 0. 120 2 -3. 005μg for honokiol. The average recovery of these two components was 99.5 % with an RSD of 0.5 % and 99.4% with an RSD of 0.5% respectively. Conclusion The method was simple, rapid , accurate as the quantity standard. |
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| Keywords: | Magnolol Honokiol HPLC Changzhong Capsules |
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