| 呋噻米对急进高原大鼠血气影响 |
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| 引用本文： | 王延玲,王荣,谢华,李文斌,马骏,陶锐,鹿辉,贾正平.呋噻米对急进高原大鼠血气影响[J].解放军药学学报,2014(2):132-134. |
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| 作者姓名： | 王延玲 王荣 谢华 李文斌 马骏 陶锐 鹿辉 贾正平 |
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| 作者单位： | [1]兰州军区兰州总医院全军高原损伤防治重点实验室,甘肃兰州730050 [2]兰州大学药学院,甘肃兰州730000 |
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| 基金项目： | 国家科技部重大资助项目,No.2008ZXJ09014-010;全军医药科研“十二五”重点项目,No.BWS12J012;全军医药科研“十二五”面上项目,No.CWS11C231 |
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| 摘 要： | 目的探讨急进4300m海拔条件下呋噻米对大鼠血气的影响。方法实验Wistar雄性大鼠40只，分为A组（平原对照组）、B组（高原对照组）、C组（高原呋噻米组）及D组（高原乙酰唑胺组）4组。在各处标准饲养3d后腹主动脉取血测定血气。结果各组血气结果有不同程度的改变。C组与B组相比，Po2、HCT、K^＋、ctHb、CB及ctO2均下降（P〈0．05）；SatO2百分比显著升高（P〈0．05），机体有一定程度的呼吸性碱中毒或代谢性酸中毒。结论在4300m海拔低氧低气压条件下机体的血气发生一定程度的改变，应用呋噻米能一定程度改善大鼠缺氧状态。
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| 关 键 词： | 低氧低气压 血气 呋噻米 低氧血症 |
Effect of Furosemide on Blood Gas of Rats after Acute Exposure to High Altitude |
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| Institution: | WANG Yan-ling,WANG Rong, XIE Hua, LI Wen-bin, MA Jun,TAO Rui, LU Hui,JIA Zheng-pin(1 PLA Key Laboratory of High Altitale Environmandal Damage Confrol, General Hospital, Lanzhou Military Command, Lanzhou 730050, China;2 School of Pharmacy,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Objective To investigate the effect of furosemide at altitude of 4300 m on blood gas in rats. Meth-ods 40 Wistar male rates were randomly divided into 4 groups ： group A （ normal control group）, group B （ high altitude control group）, group C （high altitude furosemide group） and group D （high altitude acetazolamide group）. All the rates were anesthetized after they were standardly raised for three days, followed by detection of their blood gas. Re-suits Blood gas in each group was changed to different extents. Respiratory alkalosis and metabolic acidosis occurred. Conclusion The altitude 4300 m has some effect on blood gas and furosemide can protect tissues from damage. |
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| Keywords: | hypoxic blood gas furosemide hyoxemia |
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