| 积雪草总苷元抗抑郁作用机制的初步研究 |
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| 引用本文： | 曹尉尉,李晏,伊佳.积雪草总苷元抗抑郁作用机制的初步研究[J].解放军药学学报,2009,25(1):40-43. |
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| 作者姓名： | 曹尉尉 李晏 伊佳 |
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| 作者单位： | 1. 解放军第411医院,药械科,上海,200081
2. 第二军医大学 |
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| 摘 要： | 目的探讨积雪草总苷元的抗抑郁作用机制。方法采用育亨宾毒性增强实验、阿朴吗啡致刻板运动实验、5-羟色胺酸诱导甩头实验、单胺氧化酶抑制实验等多种动物模型探讨积雪草总苷元抗抑郁作用的可能机制。结果积雪草总苷元不协同育亨宾和阿朴吗啡对小鼠的作用，但显著增加5-羟色氨酸致小鼠甩头作用和盐酸色胺致癫痫样作用。结论积雪草总苷元抗抑郁作用可能与其增加5-羟色胺能神经系统、抑制单胺氧化酶（MAO）有关。
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| 关 键 词： | 积雪草总苷元 抑郁 机制 |
Studies on the Mechanism of Antidepressant Effect of Centella Triterpenic Genines |
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| CAO Wei-Wei,LI Yan,YI Jia.Studies on the Mechanism of Antidepressant Effect of Centella Triterpenic Genines[J].Pharmaceutical Journal of Chinese People's Liberation Army,2009,25(1):40-43. |
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| Authors: | CAO Wei-Wei LI Yan YI Jia |
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| Institution: | (Hospital 411 of Chinese PLA,Shanghai 200081 China) |
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| Abstract: | Aim To study the mechanism of antidepressant effect of Centella triterpenic genines.Methods The mechanism was examined by a yohimbine-induced lethality test,APO-induced synergistic action,5-HTP induced head-twitch test and inhibiting reuptake of monoamine neurotransmitters and monoamine oxidase inhibitor(MAOI)test.Results Centella triterpenic genines did not enhance the yohimbine-induced lethality or the apomorphine-induced stereotype and climbing behavior in mice but increased the head-twitch response evok... |
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| Keywords: | centella triterpenic genines depression mechanism |
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