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Genetic variation of 17 autosomal STR loci in the Lahu population from Yunnan and phylogenetic structure exploration among 28 populations
Institution:1. School of Forensic Medicine, Kunming Medical University, Kunming City, Yunnan Province, PR China;2. Judicial Expertise Center, Kunming Medical University, Kunming City, Yunnan Province, PR China;3. Pu''er Public Security Bureau, Pu''er City, Yunnan Province, PR China;1. Department of Legal Medicine, Hyogo College of Medicine, Hyogo, Japan;2. Division of Legal Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan;3. Center of Cause of Death Investigation, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan;4. Center for Genomic Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan;1. CHU Nancy, Pole URM, Department of Legal Medicine, Nancy F-54000, France;2. Department of Legal Medicine, Charles Nicolle Hospital, Tunis, Tunisia;3. Guilloz Imaging Department, Hôpital Central, CHU Nancy, 5400 Nancy, France;4. Aix Marseille University, CNRS, EFS, ADES, Marseille France;5. Department of Forensic Medicine, Montpellier University Hospital, Montpellier, France;1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China;2. Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, Beijing 100088, China;3. Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China;1. First Department of Forensic Science, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan;2. Department of Biostatistics, Graduate School of Medicine, Hokkaido University, Nishi 15, Kita 7, Sapporo, Hokkaido 060-8638, Japan;3. Department of Forensic Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan;1. Posgrado de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Ciudad Universitaria Cercado de Lima, Lima, Peru;2. Unidad de Biología Molecular y de Genética (UNBIMOG), Instituto de Medicina Legal y Ciencias Forenses del Ministerio Público, Lima, Peru;3. Center for Human Identification, University of North Texas Health Science Center, Ft Worth, TX 76107, USA;4. Consultant, Christiansburg, VA 24073, USA;5. Universidad Privada Peruano Alemana, Lima, Peru;6. Escuela de Posgrado, Universidad Privada Norbert Wiener, Lima, Peru;1. Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Iseigaoka 1-1, Yahatanishi, Kitakyushu, Japan;2. Department of Clinical Pathology, Kitakyushu Municipal Yahata Hospital, Ogura2-6-2, Yahatahigashi, Kitakyushu, Japan
Abstract:This study evaluated the genetic variation of 17 autosomal short tandem repeat (STR) loci included in the PowerPlex® 18D Kit. Samples of 562 unrelated healthy Lahu individuals living in Yunnan Province in southwestern China were investigated. The data were analyzed to provide information on allele frequencies and other statistical parameters relevant to the forensic population. Of the 17 loci, 16 reached the Hardy–Weinberg equilibrium after Bonferroni correction. A total of 176 alleles were identified in 17 STR loci, and allele frequencies ranged from 0.000 890 to 0.578 292. The combined discrimination power (CPD) and probability of excluding paternity (CPE) of the 17 STR loci were 0.999 999 999 999 999 999 489 and 0.999 998 301 753 122. The genetic relationships among 28 populations were also estimated.
Keywords:Short tandem repeat (STR)  Population data  Lahu ethnic minority  Yunnan Province
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