| 肾上腺皮质腺瘤与增生的神经内分泌分化特性 |
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| 引用本文： | 王杰,宿飞,程继义.肾上腺皮质腺瘤与增生的神经内分泌分化特性[J].西北国防医学杂志,2002,23(4):265-267,T003. |
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| 作者姓名： | 王杰 宿飞 程继义 |
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| 作者单位： | 1. 山东省立医院泌尿外科,山东,济南,250021
2. 上海市黄浦区疾病预防控制中心 |
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| 摘 要： | 目的 :探讨肾上腺皮质腺瘤及增生有无神经内分泌性分化。方法 :通过免疫组化方法观察肾上腺皮质腺瘤 (n =39)、增生 (n =2 4)、正常组 (n =10 )的神经丝蛋白 (NF)、神经特异性烯化酶 (NSE)、突触素 (SY)的阳性表达。结果 :腺瘤组NF阳性率35 .89% ,NSE 6 6 .6 6 % ,SY 6 1.5 3%。肾上腺皮质增生的阳性率分别为NF 12 .5 % ,NSE 37.5 % ,SY 5 0 %。且所有阳性表达均发生于伴有结节性增生的病例。与正常组比较SY阳性表达有显著意义 (P <0 .0 5 ) ,与腺瘤组比较NSE阳性表达有显著意义 (P<0 .0 5 )。结论 :肾上腺皮质腺瘤与伴有结节增生的肾上腺皮质增生有神经内分泌分化
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| 关 键 词： | 肾上腺皮质腺瘤 肾上腺皮质增生 神经内分泌分化 |
| 文章编号： | 1007-8622(2002)04-0265-02 |
Neuroendocrine differentiation in adrenocortical disease |
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| WANG Jie ,SU Fei ,CHENG Ji-yi ..Neuroendocrine differentiation in adrenocortical disease[J].Medical Journal of National Defending Forces in Northwest China,2002,23(4):265-267,T003. |
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| Authors: | WANG Jie SU Fei CHENG Ji-yi |
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| Institution: | WANG Jie 1,SU Fei 2,CHENG Ji-yi 1. |
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| Abstract: | Objective:To investigate the neuroendocrine differentiation in adrenocortical adenomas and adrenocortical hyperplasias.Methods:By immunohistochemical method, the expression of neurofilament protein(NF), neuronspecific enolase(NSE) and synaptophysin(SY) were determined in normal adrenal glands (10 cases), adrenocortical adenomas (39 cases) and adrenocortical hyperplasias (24 cases).Results:In all cases of adrenocortical adenomas, NF, NSE, SY positive rates were 35.89%, 66.66%, 61.53% , respectively. In 24 cases of adrenocortical hyperplasias, NF, NSE and SY positive expression rates were 12.5%, 37.5% and 50%, respectively.Conclusion:Neuroendocrine is different in adrenocortical adenomas and adrenocortical hyperplasias accompanied by tubers. The current study suggests that it is possible to use anti-neuroendocrine drugs in clinical treatment. |
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| Keywords: | Adrenocortical adenoma Adrenocortical hyperplasia Neuroendocrine differentiation |
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