| 巨噬细胞极化及极化调控的研究进展 |
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| 引用本文： | 唐俭,陈旭昕,韩志海.巨噬细胞极化及极化调控的研究进展[J].转化医学杂志,2019,8(6):373-376. |
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| 作者姓名： | 唐俭 陈旭昕 韩志海 |
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| 作者单位： | 北京，中国人民解放军总医院第六医学中心呼吸与危重症医学科,北京，中国人民解放军总医院第六医学中心呼吸与危重症医学科,北京，中国人民解放军总医院第六医学中心呼吸与危重症医学科 |
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| 基金项目： | 国家自然科学基金（81300050）；北京市自然科学基金（7182163） |
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| 摘 要： | 巨噬细胞是固有系统的单核吞噬细胞的亚群，具有高度可塑性和异质性，并且可以响应微环境信号进行表型/功能动态转换，包括具有不同功能的2个主要巨噬细胞亚群，即经典活化性巨噬细胞和选择活化性巨噬细胞。作者对巨噬细胞分型及其信号调控通路作一综述，探讨巨噬细胞转变为经典活化性巨噬细胞和选择活化性巨噬细胞的机制，以期为巨噬细胞相关性疾病的诊断和治疗提供新的策略。
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| 关 键 词： | 巨噬细胞 巨噬细胞极化 信号通路 |
The research progress of macrophage polarization and its regulatory mechanisms |
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| Authors: | TANG Jian CHEN Xuxin and HAN Zhihai |
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| Institution: | Department of Pulmonary and Critical Care Medicine, the Sixth Medical Center,Chinese PLA General Hospital, Beijing 100048, China,Department of Pulmonary and Critical Care Medicine, the Sixth Medical Center,Chinese PLA General Hospital, Beijing 100048, China and Department of Pulmonary and Critical Care Medicine, the Sixth Medical Center,Chinese PLA General Hospital, Beijing 100048, China |
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| Abstract: | Macrophages are a subset of mononuclear phagocytic cells of the innate immune system. Macrophages are malleable and heterogeneous cells and can undergo their phenotypically/functionally dynamic switch in response to the microenvironment signals. To our knowledge, macrophages consist of classically activated macrophages and alternatively activated macrophages. This paper reviews macrophage phenotype and polarization regulation. The investigation of the mechanisms of macrophages polarization might provide new insights into a basis for diagnosis and treatment of macrophage-associated diseases. |
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| Keywords: | Macrophage Macrophage polarization Signal pathway |
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