2003-2013年国内外转化医学文献的对比分析

目的运用文献计量学的方法探讨2003—2013年国内外转化医学的发展现状、国家间合作、学科分布以及研究热点等特点，为相关研究提供参考。方法计算机检索PubMed、Web of Science、万方数据知识服务平台、中文科技期刊数据库、中国知网期刊全文数据库和中国生物医学文献数据库，查找国内外关于转化医学研究的文献，检索时间均限定为2003年1月1日—2013年12月31日。运用Excel 2013提取文献的基本信息，社会网络分析软件Ucinet 6.0分析国家间的合作关系，HistCite 12.03进行文献时间序列分析。结果共纳入中外文转化医学研究文献4 143篇。通过对文献的国家分布及其合作情况进行分析，显示开展转化医学研究的63个国家主要集中在欧洲和北美地区，其中美国的发文量、文献的被引用频次以及与其他国家的合作度最高。从文献的期刊和学科分布来看，国外发表转化医学相关期刊的种类比国内多（711比314），刊均载文量也比国内多（4.5比2.8）。国内外转化医学研究热点主要集中在基础实验和肿瘤方面，此外国内还特别关注了中医药的转化研究。引文时间序列分析显示与转化医学研究发展相关的重要文献有50篇，主要集中在2003—2011年。结论转化医学研究是当前医学研究中的热点，欧洲和北美国家处于主导地位。国内转化医学研究水平与国外差距较大，主要体现在文献的数量、被引用情况以及与其他国家的合作度均较低。

Comparative analysis of domestic and international translational medicine literatures from 2003 to 2013

Objective Bibliometrics was used to compare the exploration difference of development status, collaboration of different countries, distribution of subjects and research highlights in translational medicine literatures from 2003 to 2013, provide a reference for related research. MethodsWe systematically searched PubMed, Web of science, Wanfang, VIP, CNKI and CBM database to collect translational medicine literatures from Jan.1 2003 to Dec.31 2013. Excel 2013 was used to extract the basic information, Ucinet 6.0 was used to analyze the collaborations among countries, and HistCite 12.03 was used to conduct time series analysis. ResultsA total of 4 143 articles from 63 countries were retrieved. Most of the articles came from European and North America, among which America was the No 1 in publishing translational articles, citation times, and collaborating with other countries. As to the distribution of journals and subjects of translational medicine literatures, we could find that the number of international journals publishing translational medicine litera tures were more than domestic journals (711 vs. 314), as well as the average number of transla tional literatures published in each journal (4.5 vs. 2.8). The research highlights of international literatures concentrated on basic experiments and cancer researches, and the domestic literatures concentrated on the above areas but also focused on the translation of traditional Chinese medicine. The results of time series analysis indicated that there were 50 articles mainly published from 2003 to 2011, which was important to the development of translational medicine. ConclusionTranslational medicine was a hot point in medical research, which was led by European and North America countries. The research level of translational medicine in our country