中老年人群肝脏脂肪含量与骨密度的相关性研究

目的探讨中老年人群肝脏脂肪含量与腰椎骨密度的相关性。方法2016年3月至6月纳入184名北京社区中老年居民,其中男68名、女116名,对其进行腹部MRI mDIXON-Quant序列扫描和腰椎定量CT(QCT)扫描,测量肝脏脂肪含量和腰1~腰3椎体骨密度。根据肝脏脂肪含量的四分位数分为四组,采用单因素方差分析比较不同肝脏脂肪含量组间骨密度及身高、体重、体质量指数(BMI)、腰围、臀围等变量的差异,并对肝脏脂肪含量和骨密度做Spearman相关性分析和偏相关分析。结果随着肝脏脂肪含量的升高,BMI、腰围呈上升趋势,而腰椎骨密度逐渐降低。肝脏脂肪含量与腰椎骨密度呈低度负相关(r=-0.203,P=0.003),校正年龄、体重之后,仍呈负相关(r=-0.291,P<0.001),男性中r=-0.283(P=0.021),女性r=-0.210(P=0.025)。结论中老年人群肝脏脂肪含量与腰椎骨密度呈低度负相关。

A correlative study of liver fat content and bone mineral density in middle-aged and elderly people

Objective To investigate the quantitative relationship between liver fat content and bone mineral density(BMD)in middle-aged and elderly people.Methods Totally 184 middle-aged and elderly community residents were recruited from March to June 2016,including 68 males and 116 females.MRI mDIXON-Quant and quantitative CT(QCT)examinations were performed to determine the content of liver fat and L1-L3 vertebral BMD.The subjects were divided into four groups according to the quartiles of liver fat content,and the baseline characteristics and other variables of different groups were were identified by using one-way analysis of Variance.The relationship between liver fat content and lumbar vertebral BMD was assessed with Spearman correlation and partial correlation analysis.Result Subjects with higher hepatic fat content had lower spine BMD and higher body mass index(BMI),waist circumference.Liver fat content was negatively correlated with BMD(r=-0.203,P=0.003).After age and body weight were controlled,the negative correlation between liver fat content and BMD was still significant(r=-0.291,P<0.001),in males(r=-0.283,P=0.021)and in females(r=-0.210,P=0.025).Conclusion Liver fat content is negatively correlated with lumbar vertebral BMD in middle-aged and elderly people.