| 实验性脑损伤早期脑组织水分和钾,钠离子含量与血脑屏障改变 |
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| 引用本文： | 徐如祥,王伯云.实验性脑损伤早期脑组织水分和钾,钠离子含量与血脑屏障改变[J].解放军医学杂志,1991,16(2):98-101. |
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| 作者姓名： | 徐如祥 王伯云 |
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| 作者单位： | 第四军医大学西京医院神经外科
(徐如祥，易声禹)，第四军医大学病理解剖教研室(王伯云) |
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| 摘 要： |
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| 关 键 词： | 脑损伤 脑水肿 血脑屏障 |
THE CHANGES OF BRAIN WATER, Na~+, K~+ CONTENTS AND BLOOD-BRAIN BAR-RIER IN ACUTE EXPERIMENTAL BRAIN INJURY |
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| Xu Ruxiang. Yi Shengyu,Wang Boyun.THE CHANGES OF BRAIN WATER, Na~+, K~+ CONTENTS AND BLOOD-BRAIN BAR-RIER IN ACUTE EXPERIMENTAL BRAIN INJURY[J].Medical Journal of Chinese People's Liberation Army,1991,16(2):98-101. |
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| Authors: | Xu Ruxiang Yi Shengyu Wang Boyun |
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| Institution: | Xu Ruxiang. Yi Shengyu,Wang Boyun. Department of Neurosurgery,Xijing Hospital,Fourth Military Medical University,Xi-an |
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| Abstract: | Brain injury was produced by a falling weight in 46 rabbits. Brain water contents were determined by the dry weight method, and their Na+. K+ contents were determined. We used both Evans' blue and colloidal gold as tracers for the evaluation of blood-brain barrier (BBB) permeability in the present study. The preliminary results showed that brain water contents were increased at 0.5h after brain injury, and became more marked at 6h, concerring with alterations in Na+ and K+ contents. Evans' blue and colloidal gold passed through BBB due to an augmentation of BBB permeability in brain injury animals. It was found that anisodamine reduced BBB permeability, therefore advantagous in the treatment of cerebral edema. |
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| Keywords: | Brain injury Cerebral edema Blood-brain barrier |
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