SARS定点收治医院工作人员SARS冠状病毒感染的危险性调查

目的了解医院工作人员感染SARS病毒的危险性。方法对与SARS患者收治相关的工作人员进行问卷调查；用酶联免疫法检测SARS冠状病毒IgG抗体。结果发放调查问卷450份，收回问卷并采集血标本441人份。接受调查者全部按照防护规定进行个人防护。5例为SARS抗体IgG阳性，均为直接接触SARS病人和(或)与SARS病人标本或衣物直接接触者，比例为5／260；非直接接触SARS病人和(或)与SARS病人标本或衣物非直接接触者，比例为0／181，二者无统计学差异。5例SARS病毒IgG抗体阳性者分别来自SARS病房、CCU病区(该病区曾发生过临床疑似SARS病人)、儿科病房和门诊、标本转送中心及洗衣班，均不符合SARS的临床可能或疑似定义。结论医院目前的防护系统是完善的。

Study on the risk of infection with SARS-coronavirus in health care workers in the designated hospital exclusively for SARS

Objective To investigate the risk rate of infection with SARS coronavirus in health care workers in an designated hospital, and to assess the effectiveness of the isolation system in prevention of nosocomial transmission of SARS. Methods Questionnaire was submitted to all health care workers related with SARS patients, and ELISA assay was performed to detect IgG antibody against SARS coronavirus for all of them. Results 450 health care workers were submitted the same questionnaire, 445 questionnaires were returned, and 441 blood samples were collected. It was confirmed that all health care workers involved had complied with the isolation guidelines as formulated by the authority of the hospital. Two hundred and sixty persons out of 441 were classified into the group who had close contact with SARS patients and/or SARS materials. Among these 260 workers, IgG antibody against SARS Coronavirus was detected in 5 of them, who had either worked in the SARS ward, CCU (where 3 SARS probable cases had stayed for a short term), paediatric ward, center for sample transference, or laundry. Therefore, there was no statistically significant difference in the risk rate between the group of workers who had close contact with SARS patients and/or SARS materials and the group without contact. Conclusion The current isolation system against SARS was effective, though might not perfect.