中国的再生医学研究:需求与转化应用

近20多年来,遗传学、发育学、干细胞生物学和组织工程学的发展,使组织修复与再生迅速发展成为新兴的“再生医学”学科.中国再生医学市场需求巨大.根据国家统计数据,损伤和中毒在中国城市医院住院疾病的构成中居第3位(占9.13％),在县级医院住院疾病的构成中居第2位(占14.07％),加上遗传、代谢等疾病,中国每年需要通过修复和再生医学手段治疗的患者在1亿人次左右.中国政府及相关部门历来重视和支持再生医学的发展.组织修复与再生理论及技术的应用涉及的疾病和损伤范围比较广泛,总体而言在干细胞生物学、器官构建和复制、组织工程基础研究和产品制造以及创伤治疗本身等方面发展迅速,部分成果开始转化应用,得到国际同行的广泛关注.今后10年,中国再生医学的制度和法规将进一步健全；转化基地规模化建设速度将进一步加快；在干细胞诱导分化与多组织同步修复再生、组织工程大器官构建、组织工程产品规模化应用等方面有望取得突破性进展.

Study of regenerative medicine in China: demands and clinical translation

The repair and regeneration of tissue is a well-discussed topic.Over the past 20 years,with the development of genetics,auxology,stem cell biology,and organizational engineering,tissue repair and regeneration have rapidly developed as emergent "Regenerative Medicine".Regenerative medicine has significant market demand in China.Based on national statistics,injury and poisoning rank third in afflictions in city hospitals(accounting for 9.13%) and rank second in afflictions in county hospitals(accounting for 14.07%).Approximately 0.1 billion patients suffering from traumatic,genetic and metabolic diseases in China demand reparative and regenerative medical treatment each year.The Chinese government and its related departments have always attached great importance and support to the development of regenerative medicine,and the Chinese academic circle is involved in a very wide range of diseases and injuries involving regenerative medical theory and technology.Stem cell biology,organ engineering and duplication,tissue engineering research and production have developed rapidly,and great portion of these studies have started to appear in applications,which have aroused extensive concerns in international professional circle.In the next 10 years,the Chinese regenerative medical system will be further improved,in both statute and rules,clinical translation will be further accelerated.Breakthroughs are expected in induced differentiation of stem cells and synchronous repair and regeneration of multiple organs,construction creation of major organs by organizational engineering,and largescale applications of organizational engineering,among other aspects.