Value of (18F)-FDG positron emission tomography, computed tomography, and magnetic resonance imaging in diagnosing primary and recurrent ovarian carcinoma |
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Authors: | R A Kubik-Huch W Dörffler G K von Schulthess B Marincek O R Köchli B Seifert U Haller H C Steinert |
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Institution: | Department of Radiology, Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland. |
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Abstract: | The aim of this study was to compare prospectively the accuracy of whole-body positron emission tomography (PET), CT and
MRI in diagnosing primary and recurrent ovarian cancer. Nineteen patients (age range 23–76 years) were recruited with suspicious
ovarian lesions at presentation (n = 8) or follow-up for recurrence (n = 11). All patients were scheduled for laparotomy and histological confirmation. Whole-body PET with FDG, contrast-enhanced
spiral CT of the abdomen, including the pelvis, and MRI of the entire abdomen were performed. Each imaging study was evaluated
separately. Imaging findings were correlated with histopathological diagnosis. The sensitivity, specificity and accuracy for
lesion characterization in patients with suspicious ovarian lesions (n = 7) were, respectively: 100, 67 and 86 % for PET; 100, 67 and 86 % for CT; and 100, 100 and 100 % for MRI. For the diagnosis
of recurrent disease (n = 10), PET had a sensitivity of 100 %, specificity of 50 % and accuracy of 90 %. The PET technique was the only technique
which correctly identified a single transverse colon metastasis. Results for CT were 40, 50 and 43 %, and for MRI 86, 100
and 89 %, respectively. No statistically significant difference was seen. Neither FDG PET nor CT nor MRI can replace surgery
in the detection of microscopic peritoneal disease. No statistically significant difference was observed for the investigated
imaging modalities with regard to lesion characterization or detection of recurrent disease; thus, the methods are permissible
alternatives. The PET technique, however, has the drawback of less accurate spatial assignment of small lesions compared with
CT and MRI.
Received: 9 April 1999; Revised: 22 June 1999; Accepted: 25 August 1999 |
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Keywords: | : Ovarian cancer Lesion characterization Recurrence PET CT MRI |
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