低剂量半身照射对恶性肿瘤患者免疫功能的影响

目的 评价低剂量辐射对恶性肿瘤患者免疫功能的影响。方法 将20例患者(其中非何杰金氏淋巴瘤13例、小细胞肺癌7例)随机分为两组:HBR组和RR组。其中HBR组10例患者采用常规放疗(RR)加低剂量半身照射,低剂量半身照射方法为10 cGy/次,2次/周,总剂量为100 cGy,每次均间隔6～8 h再行常规放疗;RR组10例患者只予以常规放疗。采用流式细胞术(FCM)双标法检测HBR与RR组在放疗前、中、后外周血淋巴细胞CD₄、CD₈、CD₂₅和CD₅₆等指标的变化。结果 照射后RR组患者的CD₄⁺ CD₈⁺降低(P<0.05),HBR组患者的CD₄⁺升高(P<0.05),CD₂₅⁺和CD₅₆⁺分子表达均明显地增加(P<0.05),放疗前和放疗后CD₈⁺均低(P<0.05),放疗中(P<0.05)和放疗后(P<0.01)CD₄⁺ CD₈⁺均高。结论 低剂量半身照射可增强机体的免疫功能。

Effects of low dose half-body irradiation on immune function in patients with malignant tumor

Objective To evaluate the effects on the immune function by low dose half-body irradiation. Methods Twenty patients, 13 non-Hodgkin's lymphoma and 7 small cell lung cancer, were randomly divided into two groups: HBR and RR. 10 patients of HBR were administrated with routine radiotherapy and low dose of half-body irradiation with 10 cGy once, twice every week. The routine radiotherapy was performed 6-8 h after low dose half-body irradiation and the total dose is 100 cGy. The other 10 patients of RR were given with routine radiotherapy alone. The changes in CD₄, CD₈, CD₂₅ and CD₅₆ of the peripheral blood lymphocyte between HBR and RR were measured by flow cytometry pro-, midst- and post-radiotherapy.Results The CD₄⁺ CD₈⁺ for RR patients was decreased after irradiation (P<0.05). For HBR patients, CD₄⁺, as well as the expression of CD₂₅⁺ and CD₅₆⁺ molecule were significantly increased (P<0.05,P<0.05).CD₈⁺ was decreased pro-, post-radiotherapy (P<0.05), but CD₄⁺ CD₈⁺ was increased midst-(P<0.05) and post-radiotherapy (P<0.01). Conclusions Low dose half-irradiation could enhance the immune function.