人类免疫缺陷病毒阳性恶性肿瘤患者放射治疗的急性放射性反应观察

目的 观察并评估人类免疫缺陷病毒(HIV)阳性的肿瘤患者放射治疗的急性放射性反应。方法 回顾性分析云南省肿瘤医院2008年2月至2013年12月收治的14例HIV阳性恶性肿瘤患者,在接受放射治疗期间和治疗后1个月的放射不良反应。急性反应依据照射部位分类,参照不良事件通用术语标准(CTCAE 3.0版)分级。结果 7例患者放疗中断或延期,2例未完成放疗。皮肤、黏膜反应多见,如皮炎、咽炎、腹泻。8例患者放疗期间出现3级急性放射反应,其中,6例患者有3级皮肤反应,2例有3级黏膜反应。结论 放射治疗对HIV阳性的肿瘤患者是一种有效的治疗手段,但会引发重的急性放射反应。

Acute adverse effects of radiotherapy on HIV-positive patients with malignancy

Objective To observe and evaluate acute toxicities in a series of human immunodeficiency virus (HIV)-positive cancer patients receiving radiation therapy. Methods The study retrospectively reviewed the acute radiation reaction of radiation therapy of 14 HIV seropositive patients diagnosed with carcinoma between Feb 2008 and Dec 2013 at the Yunnan Tumor Hospital during the radiotherapy period and 1 month following treatment. Acute adverse effects were classified according to the site of radiation therapy and analyzed using the Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. Results Seven patients experienced interruptions or delays in treatment, and 2 stopped treatment entirely. The most common acute adverse effects were skin reactions and mucous membrane reactions, including dermatitis, stomatitis or diarrhea. Eight patients had grade 3 acute adverse effects, including 6 patients with grade 3 skin reactions and 2 patients with grade 3 mucosa reactions. Conclusions Radiotherapy is an effective treatment for HIV positive patients with tumors, however it frequently induced severe acute radiation responses.