黄芪总黄酮对犬模拟肺癌术中放疗抗辐射损伤作用的研究

电离辐射作用机体后可产生自由基，作者以模拟肺癌术中放疗的动物为实验对象，研究了黄芪总黄酮（ＴＦＡ）可清除自由基功效从而了解其抗辐射损伤作用。结果表明ＴＦＡ可有效的防止术中放疗所致的组织细胞损伤，使照射后组织的ＭＤＡ含量下降，ＳＯＤ活性受到保护，减轻肺组织充血、实变，胸膜粘连和食道粘膜糜烂等反应，并证明肺癌术中放疗可因电离辐射而产生自由基损伤。这种损伤不仅发生在胸腔内直接受照射的组织，在其他远隔部位的组织亦可发生。提示在实施肺癌术中放疗时不但应加强对胸腔内重要脏器的屏蔽保护，也应该加强对远隔组织的防护。

Experimental study on anti-radiation effectivenss of astragalus total flavonoids

The anti-radiation effectiveness of total flavonoids of astragalus mongholicus Bunge(TFA)has been studied with the model of intraoperative radiotherapy of imitative lung cancer.The results showed that some tissues have been protected from damage by intravenous administration of TLA before rsdiotherapy.The malonyldialdebyde concentration decreascd in trssue homogenate,while the superoxide dismutase activity did not fall.The results also show that the intraoperative radiotherapy may generate a large number of free radicals, which induce tissue and cell damage not only at the place of direct irradiation,but also at the remote places.It is suggested that the TLA has the effect of anti-radiation.The mechanism may be related to TLA properties such as anti-oxidation and scavenging of free radicals.