基于品质因素评价瓦里安锥束CT成像质量与辐射剂量风险收益比

目的 分析比对不同Varian加速器平台机载千伏锥束CT（kV CBCT）系统的辐射剂量和成像质量,指导临床选用风险收益比（成像质量/辐射剂量）最高的图像引导方案。方法 利用CT剂量指数模体（CTDI模体）和CT电离室,以及Catphan604模体分别获取Edge、Truebeam、新旧两台ix加速器机载CBCT典型扫描模式的辐射剂量和成像质量参数,使用品质因素（figure of merit,FOM）值评估各图像引导方案的风险收益比。结果 不同型号的瓦里安加速器配置的kV CBCT系统的FOM不同,差异广泛分布于0.65（温和成像一圈）~48.46（温和成像半圈）区间;各扫描参数间FOM也存在较大差异,均值为22.14±13.47。结论 由于设备间和参数间存在显著差异,基于实际测量的验证评估有助于临床选择合理的影像引导方案,剂量敏感患者应优先选择加权CT剂量指数（CTDI_w）低的参数和设备;对图像质量要求高的患者应优选对比度噪声比（CNR）高的方案;而普通患者则可依据风险收益比进行选择,此时品质因素FOM可为临床决策提供有利工具。

Evaluation of cost-effective ratio (imaging quality vs. radiation dose) of Varian cone beam CT based on figure of merit (FOM)

Objective To analyze and compare the radiation dose and image quality of kilo-voltage cone beam CT systems on different Varian accelerator platforms, providing data to support clinical decisions on selecting optimal protocols for image-guided radiotherapy based on cost-effective ratio (image quality/radiation dose). Methods The radiation dose and image quality of various CBCT systems and scanning protocols on Varian Edge, Truebeam and ix (new and old) LINACs were obtained using a CT dose index (CTDI) phantom combined with a CT ionization chamber and a Catphan604 phantom, respectively. Figure of merit (FOM) was used to evaluate the cost-effective ratio of the image guidance schemes. Results Considerable inter-system varieties of FOMs were observed, varying from 0.65 (Image Gently-full trajectory) to 48.46 (Image Gently-half trajectory). The inter-protocol varieties were also large, where the mean±SD was 22.14±13.47. Conclusions Considering the explicit inter-system and inter-protocol varieties, it is clinically favorable to evaluate the image guidance schemes based on machine-specific measurement. For instance, parameters and equipment with low CTDI_w can be beneficial for dose-sensitive patients. High CNR regimen favors patients with high image quality requirements. For ordinary patients, cost-effective ratio in terms of FOM can be very helpful to guide the decision-making of clinical image-guided radiotherapy.