首页 | 本学科首页   官方微博 | 高级检索  
检索        

硒对鼻咽癌患者放射治疗后细胞免疫功能的影响
引用本文:刘庆伦,李端,蔡体育.硒对鼻咽癌患者放射治疗后细胞免疫功能的影响[J].中华放射医学与防护杂志,1996,16(2):112-115.
作者姓名:刘庆伦  李端  蔡体育
作者单位:中山医科大学肿瘤研究所
摘    要:本文作者报道了硒对鼻咽癌患者放疗后细胞免疫功能影响的体外实验,结果表明:适宜浓度的硒(4.34×10-7mol/L)显著提高患者经PHA诱导的淋巴细胞转化作用:3H-TdR掺入量由(3.17±2.42)×104·min-1·10-6淋巴细胞增至(5.67±5.63)×104·min-1·10-6淋巴细胞,较对照组提高了(78.86±77.60)%,P<0.01。同时,硒还显著提高NK细胞杀伤活性:3H-TdR释放率由(27.90±9.22)%增加至(34.56±13.45)%,P<0.05,提示:硒在恢复放疗后鼻咽癌患者的免疫功能的治疗中,可能具有一定的价值。

关 键 词:硒,鼻咽癌,淋巴细胞转化,自然杀伤细胞
收稿时间:1994/11/28 0:00:00
修稿时间:1995/5/26 0:00:00

Effect of selenium on cell-mediated immunity in patients with nasopharyngeal carcinoma after radiotherapy
Liu Qinglun,Li Duan.Effect of selenium on cell-mediated immunity in patients with nasopharyngeal carcinoma after radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,1996,16(2):112-115.
Authors:Liu Qinglun  Li Duan
Institution:Cancer Institute, Sun Yat-sen University of Medical Sciences, Guangzhou, 510060;Cancer Institute, Sun Yat-sen University of Medical Sciences, Guangzhou, 510060;Cancer Institute, Sun Yat-sen University of Medical Sciences, Guangzhou, 510060
Abstract:in this article the in vitro effect of selenium on T lymphocyte transformation and NK cell activity in patients with nasopharyngeal carcinoma(NPC)after radiotherapy is reported.The results showed that sodium selenite(4.34×10-7 mol/L)significantly enhanced the lymphocyte transformation in response to PHA; the uptake of 3HTdR increased by 78. 98±77. 60% as compared with that of controls(P<0.001).And in the presence of sodium selenite at that concentration,the NK cell activity increased markedly : the specific cytotoxic release of 3H- TdR increased from 27.90 ±9.22% to 34. 56±13.45%(P<0.05).It is suggested that selenium may be valuable in immunothetapy for NPC patients after radiotherapy.
Keywords:Selenium  nasopharyngeal carcinoma  lymphocyte transformation  NK cells
本文献已被 CNKI 等数据库收录!
点击此处可从《中华放射医学与防护杂志》浏览原始摘要信息
点击此处可从《中华放射医学与防护杂志》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号