| 低剂量辐射对小鼠种植肿瘤及其放疗的影响 |
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| 引用本文： | 王献理,苏士杰,尹洪淑,冯乐平,于开君.低剂量辐射对小鼠种植肿瘤及其放疗的影响[J].中华放射医学与防护杂志,1996,16(3):157-160. |
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| 作者姓名： | 王献理 苏士杰 尹洪淑 冯乐平 于开君 |
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| 作者单位： | 白求恩医科大学放射医学研究所，白求恩医科大学第三临床学院肿瘤科 |
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| 摘 要： | 本文作者用低剂量辐射（Ｄ１）诱导的兴奋效应，探讨对小鼠种植肿瘤及其放疗的影响，结果证明：Ｄ１可降低种植肿瘤细胞的成瘤率（Ｐ＜０．０５），并抑制其生长速度（Ｐ＜０．０５）；荷瘤鼠局部放疗预先给予Ｄ１，可提高放疗效果；并进一步证明：上述改变可能与Ｄ１提高了淋巴细胞自发增殖能力，降低电离辐射诱发自由基，提高抗氧化酶活性和增加ＤＮＡ修复能力有关。
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| 关 键 词： | 低剂量电离辐射，兴奋效应，荷瘤小鼠，肿瘤放疗 |
| 收稿时间： | 1995/3/21 0:00:00 |
| 修稿时间： | 1995/7/14 0:00:00 |
Effects of low-dose ionizing radiation on tumor-bearing mice and on radiotherapy |
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| Wang Xianli,Su Shijie,Yin Hongshu.Effects of low-dose ionizing radiation on tumor-bearing mice and on radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,1996,16(3):157-160. |
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| Authors: | Wang Xianli Su Shijie Yin Hongshu |
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| Abstract: | We studied the effects of low-dose radiation on tumor-bearing mice and on radiotherapy from hormesis induced by low-dose radiation.The results show that D1 can reduce the tumor rate in mice implanted with tumor cells(P<0.05),and inhibit the tumor growth speed(P<0.05);the effects of radiotherapy on tumor-bearing mice can be enhanced by low-dose radiation.It is further demonstrated that these results are concerned with enhancement of lymphocyte spontaneous proliferation,activity of anti-oxidase,ability of DNA to restore and reduce free radical injury.The above results provide an experimental basis for increasing the efficacy of clinical tumor therapy and alleviating side-effects of radiotherapy. |
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| Keywords: | Low-dose ionizing radiation hormesis tumor-besring mice radiotherapy |
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