医疗机构放射工作人员血清中胰岛素样生长因子结合蛋白3水平的影响因素分析

目的 探究低剂量电离辐射对医疗机构放射工作人员外周静脉血清中胰岛素样生长因子结合蛋白3（IGFBP-3）表达水平的影响。方法 采用单纯随机抽样法选取183名放射工作人员纳入此次研究，按放射工种分组，其中介入放射学组37例、核医学组43例、放射治疗组48例和诊断放射学组55例。血清IGFBP-3浓度测定采用酶联免疫吸附试验。结果 4个不同工种组间放射工作人员血清IGFBP-3浓度的差异具有统计学意义（F＝6.056，P<0.05），其中介入放射学组血清IGFBP-3浓度最高（t＝2.815、3.611、3.936，P<0.05）；不同年有效剂量组间放射工作人员血清中IGFBP-3的浓度差异具有统计学意义（F＝8.380，P<0.05）。随着放射工龄和年有效剂量的增加，放射工作人员血清IGFBP-3浓度呈现上升趋势（r_s=0.202、0.151，P<0.05）。结论 血清IGFBP-3表达水平有作为反映长期慢性低剂量电离辐射累积暴露的生物标志物的潜力。

Influencing factors of serum insulin-like growth factor binding protein-3 level in radiological workers in medical institutions

Objective To investigate the influence of low-dose ionizing radiation on the expression level of serum insulin-like growth factor binding protein-3 (IGFBP-3) in radiation workers in hospitals. Methods 183 radiation workers were randomly selected and grouped by work type including interventional radiology (n=37), nuclear medicine (n=43), radiotherapy (n=48), and diagnostic radiology (n=55). The content of IGFBP-3 in the serum of radiation workers was detected by ELISA assay. Results It was observed that the expression level of serum IGFBP-3 in the four groups had significant differences (F=6.056, P<0.05), and the content of serum IGFBP-3 in the interventional radiology group was significantly higher than that of nuclear medicine, radiotherapy, and diagnostic radiology groups (t= 2.815, 3.611, 3.936, P<0.05). The concentration of IGFBP-3 in the serum of radiation workers among different annual effective dose groups was statistically different (F=8.380, P<0.05), which gradually increased with the increase of annual effective dose and length of service (r_s=0.202, 0.151,P<0.05). Conclusions The expression level of serum IGFBP-3 has the potential to be used as a biomarker to reflect the cumulative exposure of long-term chronic low-dose ionizing radiation.