射频消融联合其他介入综合技术治疗原发性肝癌研究进展

原发性肝癌（HCC）死亡率居全球第三位，而中国肝癌患者的年发病及死亡病例数均超过全球总数的50%。目前，手术仍是唯一有可能治愈HCC的首选方法，但绝大多数患者发现时已为肝癌中晚期，失去了手术机会。近年来介入微创治疗已成为不可手术切除肝癌治疗的研究热点之一，主要包括：肝动脉化疗栓塞（TACE）、局部消融治疗、放射性粒子组织间近距离放疗及体外高能聚焦超声波等。由于介入微创治疗方式多样，如何合理有序的联合应用仍是当前的研究热点。本文重点综述以射频消融为基础的各种介入综合技术手段联合应用治疗肝癌的新进展。

Research progress on radiofrequency ablation combined with other interventional techniques for treatment of primary liver cancer

The mortality rate of primary liver cancer (HCC) ranks third in the world, while the annual incidence and mortality of hepatocellular carcinoma patients in China are more than 50% of the global average. At present, surgery is still the only method that may cure HCC, but the majority of patients have no chance of surgery when found to be in the advanced stage. In recent years, interventional minimally invasive treatment has become one of the hotspots for the treatment of unresectable liver cancer, including transcatheter arterial chemoembolization (TACE) , local ablation therapy, brachytherapy between radioactive particles, and high-intensity focused ultrasound in vitro. Due to the variety of interventional minimally invasive treatment methods, how to use rational and orderly joint application is still the current research hotspot. This article mainly focuses on the new advances in the application of various interventional integrated techniques based on radiofrequency ablation for the treatment of liver cancer.