| 内侧颞叶癫痫皮层下核团改变的MR磁敏感加权成像研究 |
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| 引用本文： | 袁翠平,卢光明,张志强,王正阁,谭启富,陈光辉.内侧颞叶癫痫皮层下核团改变的MR磁敏感加权成像研究[J].临床放射学杂志,2010,29(11). |
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| 作者姓名： | 袁翠平 卢光明 张志强 王正阁 谭启富 陈光辉 |
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| 作者单位： | 南京大学医院医学院临床学院;南京军区南京总医院医学影像科;南京军区南京总医院神经外科;南京军区南京总医院神经内科; |
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| 基金项目： | 国家自然科学基金，江苏省博士后基金，南京军区重点医药卫生项目，南京军区南京总医院基金 |
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| 摘 要： | 目的 采用MR磁敏感加权成像(susceptibility weighted imaging,SWI)技术,研究内侧颞叶癫痫(mTLE)患者基底节、丘脑、脑干等区域铁物质含量的改变,揭示皮层下核团在mTLE病理生理机制中的作用.资料与方法 13例临床诊断的mTLE患者及相同数目年龄、性别匹配的正常自愿者参与了本研究,SWI数据采集在Siemens Magnetom Trio 3.0 T下进行.采用基于体素分析的方法(voxel-based analysis,VBA)比较病例组与正常对照组皮层下灰质核团信号的差异(P<0.05,联合强度与范围校正).结果 与正常对照组相比,mTLE患者双侧基底节、丘脑及脑干磁敏感信号明显降低,并且基底节、丘脑等区域的SWI信号与癫痫发病时间呈明显负相关.结论 皮层下灰质核团SWI信号的改变反映其铁含量发生改变,提示其在颞叶癫痫发生发展过程中起到重要作用.SWI可能成为一种新的应用于颞叶癫痫皮层下核团改变的研究手段.
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| 关 键 词： | 磁敏感加权成像 内侧颞叶癫痫 海马硬化 皮层下灰质核团 铁 |
The Study of Susceptibility Weighted Imaging in Subcortical Gray Matter Nuclei of Medial Temporal Lobe Epilepsy |
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| YUAN Cuiping,LU Guangming,ZHANG Zhiqiang,et al..The Study of Susceptibility Weighted Imaging in Subcortical Gray Matter Nuclei of Medial Temporal Lobe Epilepsy[J].Journal of Clinical Radiology,2010,29(11). |
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| Authors: | YUAN Cuiping LU Guangming ZHANG Zhiqiang |
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| Institution: | YUAN Cuiping,LU Guangming,ZHANG Zhiqiang,et al.School of Medical,Nanjing University,Department of Medical Imaging,Nanjing Jinling Hospital of PLA,Nanjing 210002,P.R.China |
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| Abstract: | Objective To investigate the level of iron in subcortical gray matter nuclei,and assess the physiopathologic role in medial temporal lobe epilepsy(mTLE)using susceptibility weighted imaging(SWI).Materials and Methods Thirteen patients with hippocampal sclerosis(HS)were studied using SWI at SIEMENS MAGNETOM Trio 3.0 Tesla scanner and the data were compared with thirteen healthy control volunteers whose age and gender were matched.The difference of signal intensity in subcortical gray matter nuclei of patient... |
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| Keywords: | Susceptibility weighted imaging Medial temporal lobe epilepsy Hippocampal sclerosis Subcortical gray matte nuclei Iron |
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