| 扩散张量的三维纤维束成像在多发性硬化中的应用 |
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| 引用本文： | 李郁欣,汤伟军,耿道颖,李振新,吴平.扩散张量的三维纤维束成像在多发性硬化中的应用[J].临床放射学杂志,2008,27(10). |
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| 作者姓名： | 李郁欣 汤伟军 耿道颖 李振新 吴平 |
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| 作者单位： | 1. 复旦大学附属华山医院放射科,上海,200040
2. 复旦大学附属华山医院神经内科,上海,200040 |
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| 摘 要： | 目的 应用三维纤维束成像技术,研究多发性硬化(multiple sclerosis,MS)脱髓鞘斑块引起的白质纤维束的改变. 资料与方法 应用3 T 磁共振对34例MS患者和25名非MS健康志愿者行常规头颅MRI和扩散张量成像(DTI),观察MS病灶处和正常表现脑白质的纤维束变化. 结果 三维纤维束成像可以清楚显示脑内白质纤维束的方向、形态和结构.在MS斑块处可见纤维束中断、病灶远端纤维束缺失或稀少.病灶周围的纤维束表现为受压、推移改变.与相同年龄段的正常人对照,MS患者的正常表现胼胝体内纤维束稀少. 结论 基于DTI技术的纤维束成像能够直观地显示脑内白质纤维束,反映病变对纤维造成的影响.
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| 关 键 词： | 多发性硬化 扩散张量纤维束成像 |
Three-Dimensional Diffusion Tensor Tractography in Multiple Sclerosis |
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| LI Yuxin,TANG Weijun,GENG Daoying,et al..Three-Dimensional Diffusion Tensor Tractography in Multiple Sclerosis[J].Journal of Clinical Radiology,2008,27(10). |
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| Authors: | LI Yuxin TANG Weijun GENG Daoying |
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| Institution: | LI Yuxin,TANG Weijun,GENG Daoying,et al.Daeartment of Radiology,the Affiliated Huashan Hospital of Fudan University,Shanghai 200040,P.R.China |
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| Abstract: | Objective To study the change of white matter in multiple sclerosis(MS) using diffusion tensor tractography.Materials and Methods Conventional MRI and DTI examination were performed in 34 MS patients and 25 normal volunteers.The change of fibers in MS patients and normal people was studied.Results Trajectory and integrity of white matter were directly visualized on fiber tractography.Fiber tracts were disrupted by lesions and shifted due to adjacent plaques.Absence or shortening of distal fiber bundle could... |
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| Keywords: | Multiple sclerosis Diffusion tensor tractography |
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