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| 宝石CT心肌灌注成像在缺血性心脏病动物模型中的应用 | |
| 引用本文： | 庞丽芳,张欢,杨文洁,陆伟,肖华,卜玉莲,陈颖,许伟青,潘自来,陈克敏,严福华.宝石CT心肌灌注成像在缺血性心脏病动物模型中的应用[J].临床放射学杂志,2011,30(11). |
| 作者姓名： | 庞丽芳 张欢 杨文洁 陆伟 肖华 卜玉莲 陈颖 许伟青 潘自来 陈克敏 严福华 |
| 作者单位： | 1. 200025,上海交通大学医学院附属瑞金医院放射科 2. GE公司CT产品部 3. 瑞金医院心内科 4. 上海交通大学基础医学院病理学教研室 |
| 摘 要： | 目的对不同缺血时间缺血性心脏病动物模型行CT心肌灌注扫描,评价其在诊断缺血性心脏病中的价值。材料与方法健康新西兰大白兔20只,结扎左前降支近段建立缺血性心脏病模型。于建模后6h、3天、7天、14天行CT首过心肌灌注扫描,扫描结束后取病理,行HE染色和CD31免疫组织化学检查。分析比较各组的血流灌注量(BF)、血容量(BV)、平均通过时间(MTT)之间的差异及各指标与微血管密度(MVD)间的关系。结果 (1)缺血心肌BF值随缺血时间延长其值呈下降趋势,各不同缺血时间组BF值差异有统计学意义(P<0.05);(2)缺血心肌BF值与MVD之间存在负相关rp=-0.525,P=0.018。结论宝石CT首过心肌灌注可以评估不同缺血时间缺血心肌的灌注特征,有助于定性评价缺血性心脏病。 |
| 关 键 词： | 缺血性心脏病 动物实验 心肌灌注 宝石CT |
CT Perfusion Features Correlation with Pathological Findings in Animal Model of Lschemic Heart Disease |
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| Pang Lifang,Zhang Huan,Yang Wenjie,et al..CT Perfusion Features Correlation with Pathological Findings in Animal Model of Lschemic Heart Disease[J].Journal of Clinical Radiology,2011,30(11). | |
| Authors: | Pang Lifang Zhang Huan Yang Wenjie |
| Institution: | Pang Lifang,Zhang Huan,Yang Wenjie,et al.Deparment of Radiology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,P.R.China |
| Abstract: | Objective To evaluate the application value of CT myocardial perfusion in diagnosis of animal model of ischemic heart disease.Materials and Methods 20 healthy New Zealand white rabbits were included in this study.The model of ischemic heart disease was established by ligation of the proximal left anterior descending branch.After 6 hours,3 days,7 days and 14 days of ligation,first pass myocardial perfusion CT scanning was perfomed.All the rabbits were sacrificed after CT scanning,and their hearts were perfor... |
| Keywords: | Ischemic heart disease Animal experiment Myocardial perfusion High-definition Discovery CT(HDCT) |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |