灰质异位脑功能连接的功能磁共振成像研究

目的通过观察灰质异位脑功能连接区的空间分布形式,探索灰质异位与正常脑区间的神经功能联系。方法研究对象为8例确诊为双侧灰质异位癫痫患者,经Siemens 3.0 T磁共振仪采集静息态及3D结构像数据。以异位灰质团块作为种子点,进行基于相关的全脑功能连接分析,并对异位灰质功能连接网络存在的模式进行观察分析。结果 (1)一侧异位灰质与对侧异位灰质存在正相关功能连接;(2)异位灰质与双侧基底神经节存在正相关连接。(3)异位灰质与正常大脑皮层存在正相关功能连接,但其空间模式与异位灰质所处的部位有关。(4)异位灰质与双侧大脑皮层也存在负相关功能连接区域,但其空间模式无明显一致性。结论灰质异位不是孤立的异常脑结构,其不但与对侧的异位灰质保持功能连接,还与众多大脑皮层区保持着广泛的功能连接,这可能由于异位灰质团与正常皮层具有相同起源以及相似发育过程而形成的。其与基底神经节存在功能连接可能是异位灰质经常引发癫痫发作的病理生理基础之一。

Exploring Functional Connectivity of Gray Matter Heterotopia Using fMRI

Objective To study the spatial patterns of functional connectivity of heterotypic gray matter and discuss the functional connection between lesions and normal brain regions.Methods Resting state and 3D data of 8 bilateral per ventricular nodular heterotopia(PNH) patients with epilepsy were obtained from SIEMENS Trio 3T MR scanner.Heterotopic nodules were adopted as ROIs,which were calculated as seeds in correlative analysis,and then the functional connectivity network mode of them was observed.Results Positive correlations existed between ROIs and contralateral nodules.Some cortical regions showed functional connectivity with focal nodules,moreover,focal nodules had positive correlations with basal ganglion,and also there were negative correlations between nodules and cortex,but distributing patterns had variance.Conclusion Heterotopic nodules are not self-existent,they were not only connected with contralateral ones but also with other parts of cerebrum.The connection between nodules and basal ganglion may indicate that heterotopic nodules are likely to initiate the seizures.