Long-term efficacy and urological toxicity of low-dose-rate brachytherapy (LDR-BT) as monotherapy in localized prostate cancer |
| |
Authors: | Kristiina Vuolukka Päivi Auvinen Jan-Erik Palmgren Tuuli Voutilainen Sirpa Aaltomaa Vesa Kataja |
| |
Institution: | 1. Department of Oncology, Cancer Center, Kuopio University Hospital, Kuopio, Finland;2. University of Eastern Finland, Kuopio, Finland;3. Department of Urology, Kuopio University Hospital, Kuopio, Finland;4. Central Finland Central Hospital, Jyväskylä, Finland |
| |
Abstract: | PurposeThe purpose of this study was to evaluate the incidence of late severe (≥Grade 3) urinary toxicity and the long-term efficacy after low-dose-rate brachytherapy (LDR-BT) in patients with localized prostate cancer (PCa).Methods and MaterialsDuring the years 1999–2008, 241 patients with PCa who underwent LDR-BT with I125 and were followed up in Kuopio University Hospital were included to this analysis. The incidence of late severe (Grade 3) urinary toxicity and the long-term efficacy results were analyzed.ResultsAll D'Amico risk groups were represented, as 58.9%, 35.3%, and 5.8% of the patients were classified as low-, intermediate-, and high-risk patients, respectively. With a median followup of 11.4 years after implantation, the incidence of severe urinary toxicity increased throughout the followup period. The risk of Grade 3 urinary toxicity was highest among patients with higher Gleason scores (p = 0.016) and higher initial urine residual volumes (p = 0.017) and the cumulative incidence of severe urinary toxicity was 10.0%. The crude rate for transurethral prostatic resection was 5.8%. The relapse-free survival, the cause-specific survival, and the overall survival were 79.3%, 95.0%, and 66.4%, respectively.ConclusionsThe treatment was well tolerated as 90% of patients avoided any Grade 3 urinary toxicity. LDR-BT for localized PCa achieved high and durable efficacy. These results support the role of LDR-BT monotherapy as one of the valid primary treatment options for low-risk and favorable intermediate-risk patients. |
| |
Keywords: | Corresponding author Cancer Center Kuopio University Hospital PO Box 100 FI-70029 Kuopio Finland Tel : +358-44-7172942 Prostate cancer Low-dose-rate brachytherapy Late urinary toxicity Long-term efficacy |
本文献已被 ScienceDirect 等数据库收录! |
|