| 飞行人员广泛性焦虑障碍与5-羟色胺2A受体基因多态性相关性的研究 |
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| 引用本文： | 郎晓光,刘红巾,蔡庆.飞行人员广泛性焦虑障碍与5-羟色胺2A受体基因多态性相关性的研究[J].航天医学与医学工程,2016(3):181-184. |
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| 作者姓名： | 郎晓光 刘红巾 蔡庆 |
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| 作者单位： | 1. 河北北方学院,河北张家口,075000;2. 空军总医院临床航空医学中心,北京,100142 |
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| 基金项目： | 全军医药卫生科研“十一五”计划课题(08G045) |
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| 摘 要： | 目的探讨飞行人员广泛性焦虑障碍(generalized anxiety disorder,GAD)与5-羟色2A(5-HT2A)受体基因T102C和A-1438G位点多态性的关系。方法用聚合酶链反应技术(PCR)检测19例飞行人员GAD患者及55名正常健康对照飞行人员两基因位点的多态性。结果 GAD组与健康对照组飞行人员在T102C位点基因型的构成比上不存在统计学差异(P0.05),在A-1438G位点基因型的构成比上存在统计学差异(P0.05),患者组G-1438等位基因型频率(65.8%)明显高于对照组(34.2%)。结论5-HT2A基因A-1438G位点多态性可能与飞行人员GAD相关,G-1438等位基因可能是飞行人员GAD的一个易感基因。
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| 关 键 词： | 飞行人员 广泛性焦虑障碍 5羟色胺 基因多态性 |
Research on Correlation Between Generalized Anxiety Disorder and Polymorphism of 5-HT2A Gene in Pilots |
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| Abstract: | Objective To study the correlation between T102C and A-1438G polymorphism of 5-Hydroxytryptamine 2A receptor (5-HT2A) gene with generalized anxiety disorder (GAD)in pilots.Methods 5-HT2A gene genotype was assayed with polymerase chain reaction (PCR)in 19 GAD pilots and 55 health control pilots.Results There was no significant difference between GAD pilots and controls in T102C (P ＞ 0.05).There were significant differences between GAD pilots and controls in constituent ratio of A-1438G (P ＜0.05).The frequency of G-1438 allele in GAD pilots (65.8％) was significantly higher than that in controis(34.2％).Conclusion The polymorphisms of A-1438G in 5-HT2A gene may be correlated with GAD in pilots;G-1438 allele may be a susceptible gene for pilots with GAD. |
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| Keywords: | pilots generalized anxiety disorder 5-Hydroxytryptamine gene polymorphism |
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