E-cadherin蛋白在前列腺癌组织中的表达及临床意义

目的　探讨上皮细胞钙粘素 (E cadherin ,E Cad)在前列腺癌组织中的表达及其临床意义。方法　应用免疫组织化学 (SP)方法测定 42例前列腺癌及 3例正常和 7例良性前列腺增生组织中E Cad蛋白的表达。结果　 42例前列腺癌组织中 2 1例E Cad蛋白表达阳性 ( 5 0 %)。随肿瘤细胞病理分级、临床分期程度的增高 ,癌细胞表达E Cad蛋白阳性率降低 ,高、中分化组 2 2例前列腺癌中 19例E Cad蛋白表达阳性( 86%) ,与低分化组 2 0例中 2例 ( 10 %)阳性表达 ;A +B期和C +D期前列腺癌组织中的阳性表达率分别为 65 5 %( 19/ 2 9)和 15 3 %( 2 / 13 ) ,各组间比较有显著性差异 ( χ2 =2 4 43 ,P <0 0 0 5 ;χ2 =9 0 3 ,P <0 0 0 5 )。而正常和良性前列腺增生组E Cad蛋白均呈阳性免疫反应。结论　E Cad蛋白异常表达在前列腺癌的恶性进展中起重要作用 ,检测E Cad蛋白的表达有利于判断病期及预后。

Expression of E-cadherin in Prostate Cancer and Its Significance

Objective To investigate the expression of E cadherin (E Cad) in primary prostate cancer and its clinical significance.Methods E Cad protein expression in paraffin embedded tissue of 42 prostate cancer, 3 normal prostate tissue and 7 benign prostate hyptertrophy sample were analysed by immunohisochemical staining.Results The positive rate of E Cad was 50.0% (21/42) in primary prostate cancer. The higher grade and higher clinical stage of tumor were,the lower expression of E Cad.The positive rate of E Cad in well or moderately differentiated type and in poor differentiated type were 86.3%(19/22) and 10.0%(2/20)(χ 2=24 43, P <0.005) respectively.The positive rate of E Cad in A+B stages in C+D stages were 65.5% (19/29 ) and 15.3% (2/13) (χ 2=9.03, P <0.005) respectively.But 10 cases with normal and benign iesion were all positive staining.Conclusion The abnormal expression of E Cad may play an important role in primary prostate cancer progression, E Cad examination is useful for the judgement of tumor development and prognosis.