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FOLFOX4化疗联合全身热疗治疗晚期大肠癌的临床观察
引用本文:王小文,钟美佐.FOLFOX4化疗联合全身热疗治疗晚期大肠癌的临床观察[J].临床军医杂志,2012,40(1):120-122.
作者姓名:王小文  钟美佐
作者单位:中南大学湘雅医学院,湖南 长沙,410007
摘    要:目的观察FOLFOX4方案化疗联合太空舱全身热疗治疗晚期直肠癌的近期疗效及安全性。方法将2008年1月—2010年12月收治的38例晚期结、直肠癌患者,分为两组,观察组20例在深度镇静下行FOLFOX4方案化疗联合太空舱全身热疗仪进行全身热化疗,对照组18例采用FOLFOX4方案进行化疗。结果观察组有效率(RR)60.0%,疾病控制率(DCR)80.0%;对照组RR 27.8%,DCR 44.4%。两组间RR、DCR比较差异均有统计学意义(P<0.05)。观察组与对照组的主要化疗毒副反应为骨髓抑制及恶心、呕吐等,两组间比较差异无统计学意义(P>0.05)。观察组中出现Ⅰ~Ⅱ度皮肤烧伤4例,无一例出现急性心肺功能衰竭。结论采用太空舱全身热疗系统联合FOLFOX4方案进行全身热化疗治疗晚期结、直肠癌安全有效。

关 键 词:全身热疗  大肠癌  FOLFOX4方案

Clinical observation on FOLFOX4 regimen combined with the whole body hyperthermia in the treatment of advanced colorectal cancer
Wang Xiao-wen , Zhong Mei-zuo.Clinical observation on FOLFOX4 regimen combined with the whole body hyperthermia in the treatment of advanced colorectal cancer[J].Clinical Journal of Medical Officer,2012,40(1):120-122.
Authors:Wang Xiao-wen  Zhong Mei-zuo
Institution:(Xiangya Medical College of Central South University,Changsha Hunan 410007,China)
Abstract:Objective To observe the short-term efficacy and safety of FOLFOX4 regimen combined with the whole body hyperthermia(WBH) in the treatment of advanced colorectal cancer.Methods From January 2008 to December 2010,38 advanced colorectal cancer patients were divided into two groups.The observation group(n=20) was treated with FOLFOX4 regimen combined with the WBH after the patients sedated.The control group(n=18) was treated with FOLFOX4 regimen only.Results The response rate(RR) was 60.0% in the observation group and 27.8% in the control group;the disease control rate(DCR) was 80.0% in the observation group and 44.4% in the control group.There was statistical difference in RR and DCR between the two groups(P<0.05).The major side effects include bone marrow suppression,nausea and vomiting,et al.However,the difference was not statistically between the two groups(P>0.05).There were only 4 patients with Ⅰ~Ⅱdegree skin burn in the observation group and none has acute respiration failure.Conclusion The treatment of advanced colorectal cancer by FOLFOX4 regimen combined with whole body hyperthermia is effective and safe.
Keywords:whole body hyperthermia  colorectal cancer  FOLFOX4 regimen
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