多体素~1H-MRS对星形细胞肿瘤边界诊断的研究

目的：探讨多体素^1H-MRS在星形细胞瘤边界诊断中的临床应用价值。方法：对20例经病理证实的星形胶质细胞瘤患者行多体素^1H-MRS检查,采集NAA、Cho、Cr等波峰,计算并比较肿瘤不同区域多种代谢物比值。结果：多体素^1H-MRS示肿瘤区、近侧瘤周区NAA/Cho、NAA/Cr和Cho/Cr平均值与参照区比较差异均有显著性意义（P〈0.05）;高、低级星形细胞瘤间,多组代谢物比值差异具有统计学意义（P〈0.05）。结论：MRS示Ⅲ～Ⅳ级星形细胞瘤在肿瘤区边缘2cm范围代谢物比值仍和参照区差异有显著统计学意义,提示存在肿瘤浸润,Ⅰ～Ⅱ级星形细胞瘤在肿瘤区边缘1cm范围代谢物比值仍和参照区差异有显著统计学意义,提示存在肿瘤浸润。

Value of multivoxel 1H-MRS in evaluating the border of astrocytoma

Objective：To investgate the value of multivoxel ^1H-MRS in evaluating the border of astrocytoma.Methods：20 cases of astrocytoma were all examined by routine MR scan and ^1H-MRS.Spectra of different areas were taken and fitted areas in the spectrum for NAA,Cho,Cr and other metabolite peaks were measured and calculated for each voxel.Results：In multivoxel ^1H-MRS from enhanced and perienhancement areas of the lesion,the ratios of NAA/Cho,NAA/Cr and Cho/Cr changed significantly when compared with those of normal brain tissues （P〈0.05）.Between high and low grade astrocytic tumors,the mean values of different metabolite peak ratios revealed strong correlations.Conclusion：Multivoxel ^1H-MRS is useful in defining the border of tumors and making the histological classification of astrocytoma.