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| HER-2阳性乳腺癌PET及SPECT靶向探针研究进展 | |
| 引用本文： | 陈旖文,李小凤,尹国涛,陈薇.HER-2阳性乳腺癌PET及SPECT靶向探针研究进展[J].国际医学放射学杂志,2021,44(4):456-460. |
| 作者姓名： | 陈旖文 李小凤 尹国涛 陈薇 |
| 作者单位： | 天津医科大学肿瘤医院,分子影像及核医学诊疗科,天津 300060;天津医科大学肿瘤医院,分子影像及核医学诊疗科,天津 300060;国家肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津市恶性肿瘤临床医学研究中心;乳腺癌防治教育部重点实验室 |
| 基金项目： | 天津市自然科学基金京津冀基础研究合作专项(H2018206600) |
| 摘 要： | HER-2阳性乳腺癌的恶性度高,易复发和转移。正电子发射体层成像（PET）和单光子发射体层成像（SPECT）可特异性提供靶组织的HER-2表达信息,并能对乳腺癌的疗效及预后实时评估,在乳腺癌诊疗过程中发挥了重要作用。随着HER-2靶向分子探针研究不断深入,降低正常器官和组织的非特异性摄取成为研究的重点。对PET及SPECT成像的HER-2分子靶向探针作一介绍,并综述HER-2分子探针的应用现状及进展,客观分析各种靶向探针的优势及不足。 |
| 关 键 词： | HER-2 乳腺癌 靶向成像 分子成像 正电子发射体层成像 单光子发射体层成像 分子探针 |
| 收稿时间： | 2020-10-22 |
Progress in HER-2-targeted probes for PET and SPECT imaging in breast cancer |
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| CHEN Yiwen,LI Xiaofeng,YIN Guotao,CHEN Wei.Progress in HER-2-targeted probes for PET and SPECT imaging in breast cancer[J].International Journal of Medical Radiology,2021,44(4):456-460. | |
| Authors: | CHEN Yiwen LI Xiaofeng YIN Guotao CHEN Wei |
| Institution: | 1 Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 2 National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer 3 Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education |
| Abstract: | Breast cancer with HER-2 positive is more invasive and more likely to present recurrence and metastasis. Positron emission tomography (PET) and single photon emission tomography (SPECT) can specifically provide the information of HER-2 expression in target tissues, this can be used to evaluate the efficacy and prognosis of breast cancer in real time, which plays an important role in the diagnosis and treatment of breast cancer. With the deepening of HER-2 targeting molecular probe research, it has become the focus of research to reduce the non-specific uptake of normal organs and tissues. This article reviews the HER2-targeting probes used for PET and SPECT imaging in recent years, and analyzed the advantages and disadvantages of those probes. |
| Keywords: | HER-2 Breast cancer Targeted imaging Molecular imaging Positron emission tomography Single photon emission computed tomography Molecular probe |
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