| MR靶向分子成像在胰腺癌早期诊断中的研究进展 |
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| 引用本文： | 李登峰,马霄虹,赵心明.MR靶向分子成像在胰腺癌早期诊断中的研究进展[J].国际医学放射学杂志,2020(1):63-67,82. |
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| 作者姓名： | 李登峰 马霄虹 赵心明 |
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| 作者单位： | 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院影像诊断科 |
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| 基金项目： | 国家自然科学基金（81671757） |
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| 摘 要： | 胰腺癌起病隐匿、侵袭性强,早期诊断是提高胰腺癌总体生存率及改善预后的关键。分子成像可以发现疾病发展过程中分子或细胞水平的早期异常变化,能够早期诊断胰腺癌病灶。就MR靶向分子成像技术原理、胰腺癌早期诊断相关受体和蛋白抗原标志物分子靶点选择以及以钆和磁性纳米颗粒为基础的MR靶向分子成像在胰腺癌早期诊断研究中的应用和进展予以综述。
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| 关 键 词： | 分子成像 磁共振成像 胰腺癌 靶向 |
Application of MR target molecular imaging in early diagnosis of pancreatic cancer |
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| LI Dengfeng,MA Xiaohong,ZHAO Xinming.Application of MR target molecular imaging in early diagnosis of pancreatic cancer[J].International Journal of Medical Radiology,2020(1):63-67,82. |
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| Authors: | LI Dengfeng MA Xiaohong ZHAO Xinming |
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| Institution: | (Department of Imaging Diagnosis,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China) |
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| Abstract: | Pancreatic cancer(PC)is characterized by insidious onset and high invasiveness,and early detection is the key to improving overall survival and prognosis of PC.Molecular imaging makes the early diagnosis of PC possible,and it can detect early abnormal changes at the molecular or cellular levels in the preliminary stage.In this review we provided a summary of technical principle of MR targeted molecular imaging and highlighted the application and progresses in selection of receptors and protein antigen biomarkers,and MR targeted molecular imaging based on Gd or magnetic nanoparticle(MNP)in the early diagnosis of PC. |
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| Keywords: | Molecular imaging Magnetic resonance imaging Pancreaticcancer Target |
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