肝移植术后认知与脑改变的多模态神经成像

肝性脑病是终末期肝硬化的重要并发症,导致病人出现一系列神经及认知功能改变。肝移植术后病人在肝功能恢复的同时其认知功能也可明显改善。MRI可以从脑代谢、结构及功能方面更进一步揭示肝硬化病人移植术后认知及脑改变情况。综述肝移植术后认知改变的研究现状以及最新的多模态MRI技术在术后脑改变中的应用,及其在揭示术后认知恢复及残存损害的神经机制中的价值。

Multimodal neuroimaging: the cognition and brain alterations after liver transplantation

Hepatic encephalopathy(HE)is an important complication of end-stage cirrhosis which can leads to a series of neurological and cognitive changes.Liver transplantation(LT)can effectively restore the liver function,thus the impaired cognitive function can be greatly corrected.MRI offers a variety of techniques for non-invasive evaluation of alterations in metabolism,cognition,and structures of brain in the cirrhotic patients after LT.In this article,we reviewed the current research status concerning post-surgery cognitive alterations,as well as the application of multimodal magnetic resonance imaging in assessing brain alterations after LT,and its value in revealing the neurological mechanism underlying the recovery and residual impairment of cognitive.