国内负压创面治疗技术临床研究现状的循证分析

目的 采用循证医学的方法,对国内负压创面治疗技术的临床现状进行系统性研究. 方法 系统性检索2008年12月前国内发表的关于负压创面治疗技术的文献,并对结果进行证据分级和质量等级的评估. 结果 检索到符合标准的文献5篇(均为随机对照试验):1篇证据分级为1b,质量等级为"优",余4篇证据分级为2b,质量等级为"差". 结论 对于负压技术相对宽泛的适应证,目前国内缺乏足够的证据证明其疗效.今后需进一步规范该技术的科学研究及临床应用,包括注重选题和立题的创新性、试验设计的完善性和实用性、治疗过程的标准化等问题.提高发表文献的质量,以更好地指导临床工作.

Evidence-based medicine analysis on current clinical research status of negative pressure wound therapy in China

Objective To systematically review the current research status of negative pressure wound therapy in China based on method of evidence-based medicine (EBM). Methods A systematic retrieval was undertaken on literatures related to negative pressure wound therapy in China. Evidence grading of EBM and quality rating system of preventive service task force were used for evaluation of the results. Results We finally retrieved five randomized controlled trials (RCT), of which only one RCT was classified as good quality and high grade of evidence, whereas the other four were classified as poor quality and low grade of evidence. Conclusions With relatively wide indications, there still lack sufficient evidences to witness the clinical efficiency of NPWT in China. in the future, we should further researches on NPWT including emphasizing on novelty of research topics and intactness and usefulness of experimental design and standardize clinical application of such technique including standardization of treatment procedures. In the meantime, high quality research papers are needed to provide certain guidance for clinical therapy.