| 脓毒症大鼠急性肺损伤血清IL-6、IL-17的变化及其意义 |
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| 引用本文： | 熊燚,王兴勇.脓毒症大鼠急性肺损伤血清IL-6、IL-17的变化及其意义[J].儿科药学杂志,2010,16(1):11-12,34. |
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| 作者姓名： | 熊燚 王兴勇 |
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| 作者单位： | 1. 贵州省遵义市妇女儿童医院,贵州遵义,563000
2. 重庆医科大学附属儿童医院,重庆,400014 |
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| 摘 要： | 目的：研究脓毒症大鼠急性肺损伤（ALI）血清IL-6、IL-17水平，以探讨IL-6和IL—17与ALI的关系及可能机制。方法：SD雄性大鼠20只随机分为对照组和模型组各10只。静脉注射脂多糖（6mg／kg）复制ALI的动物模型，观察12h后活杀。测定肺湿／干重比，石蜡包埋切片HE染色行肺组织病理评分，用ELISA法检测血清IL-6、IL-17水平。结果：与对照组相比，模型组肺影干重比为（5．505±0．237）、肺组织病理评分（2．579±0．146）、血清IL-6水平（1501．511±402．401）pg／mL]、IL-17水平（49．830±11．464）pg/mL]均明显增高，t值分别是11．356、32．769、43．875、112．674，P均〈0．05。血清IL-6、IL-17水平与肺病理组织评分相关系数及P值分别为r=0．7168，P=0．0004；r=0．937，P〈0．0001。肺组织损伤程度与血清IL-6和IL—17水平呈正相关。结论：IL—17可能参与了脓毒症所致的肺损伤过程。
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| 关 键 词： | 肺损伤 白介素-17 白介素-6 |
The Change of Serum IL-6,IL-17 on the Acute Lung Injury of Sepsis Rats and Its Significance |
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| XIONG Yi,WANG Xing-yong.The Change of Serum IL-6,IL-17 on the Acute Lung Injury of Sepsis Rats and Its Significance[J].Journal of Pediatric Pharmacy,2010,16(1):11-12,34. |
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| Authors: | XIONG Yi WANG Xing-yong |
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| Institution: | 1. Woman and Children's Hospital of Zunyi;Guizhou Province;Guizhou Zunyi 563000;China;2. Children's Hospital of Chongqing Medical University;Chongqing 400014;China |
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| Abstract: | Objective:To study the serum level of IL-17 and IL-6 in the sepsis-induced acute lung injury (ALI) in rats,and to probe the relation of IL-17 and IL-6 serum level to ALI and its possible mechanism. Methods:The twenty SD male rats were randomly assigned to two groups:a control group and a model group. ALI was induced by intravenous injection of LPS (6 mg/kg) and those animals were killed after twelve hours. The lung wet/dry weight ratio,lung pathologic tissue score with hematoxylin and eosin (HE) stain,the s... |
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| Keywords: | Lung injury Interleukin-17 Interleukin-6 |
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