酒石酸布托啡诺、盐酸曲马多及昂丹司琼注射剂体外配伍稳定性考察

目的:考察酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液在0.9%氯化钠注射液中的配伍稳定性。方法:采用HPLC法测定配伍液中三种药物含量,考察三种药物在0.9%氯化钠注射液中,室温条件下72 h内的含量变化,同时观察与检测外观与pH变化。结果:酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液的配伍液在72 h内三种药物含量未见明显变化,配伍液外观澄清,pH值保持稳定。结论:酒石酸布托啡诺、盐酸曲马多及盐酸昂丹司琼在0.9%氯化钠注射液中室温条件下、72 h内保持稳定。

Stability of in Vitro Compatibility of Butofenol Tartrate, Tramadol Hydrochloride and Ondansetron Injection

Objective: To investigate the compatible stability of butorphanol tartrate, tramadol hydrochloride and ondansetron hydrochloride in 0.9% sodium chloride injection. Methods: HPLC method was adopted to determine the content of 3 drugs in the compatibility solution. The content changes of 3 injections in 0.9% sodium chloride injection at room temperature for 72 hours were investigated, and changes of appearance and pH values were observed and tested. Results: The compatibility of butofenol injection, tramadol hydrochloride injection and ondansetron hydrochloride injection did not change significantly in the content of 3 drugs within 72 hours. The appearance of the compatibility solution was clarified and the pH values remained stable. Conclusion: Butorphanol tartrate injection, tramadol hydrochloride injection and ondansetron hydrochloride injection were stable in 0.9% sodium chloride injection at room temperature for 72 h.