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| 抗焦虑药物对束缚应激大鼠作用的分子机制探索 | |
| 引用本文： | 黄欢捷,邵蓓,郑荣远,李剑敏,王宗敏,颜志钦,谢丽薇.抗焦虑药物对束缚应激大鼠作用的分子机制探索[J].中国临床药理学与治疗学,2004,9(10):1134-1136. |
| 作者姓名： | 黄欢捷 邵蓓 郑荣远 李剑敏 王宗敏 颜志钦 谢丽薇 |
| 作者单位： | 1. 温州医学院附属一院神经内科,温州,325000,浙江 2. 温州医学院病理科,温州,325000,浙江 3. 温州医学院附属二院病理科,温州,325000,浙江 4. 温州医学院附属三院神经内科,温州,325000,浙江 |
| 基金项目： | 浙江省重点学科基金资助项目(№xxf99005) |
| 摘 要： | 目的：为了探讨抗焦虑药物治疗焦虑症状的分子作用机制。方法：建立大鼠束缚应激模型，观察抗焦虑药物帕罗西汀用药组大鼠的旷场行为和下丘脑c-fos的表达。结果：与正常对照组比较，应激大鼠在旷场中的穿行格数和直立次数明显增加，下丘脑室旁核c-fos表达显著增加，而帕罗西汀用药组能减少大鼠在旷场中的活动和下丘脑室旁核c-fos表达。结论：帕罗西汀对束缚应激大鼠脑保护作用可能与下调c-fos基因表达有关。 |
| 关 键 词： | 帕罗西汀 应激 行为 c-fos 下丘脑 室旁核 |
| 文章编号： | 1009-2501(2004)10-1134-03 |
| 修稿时间： | 2004年8月9日 |
Molecular mechanisms of antianxiety drugs on rats with restraint stress |
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| HUANG Huan Jie,SHAO Bei,ZHENG Rong Yuan,LI Jian Min ,WANG Zong Min ,YAN Zhi Qin ,XIE Li Wei.Molecular mechanisms of antianxiety drugs on rats with restraint stress[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2004,9(10):1134-1136. | |
| Authors: | HUANG Huan Jie SHAO Bei ZHENG Rong Yuan LI Jian Min WANG Zong Min YAN Zhi Qin XIE Li Wei |
| Institution: | HUANG Huan Jie,SHAO Bei,ZHENG Rong Yuan,LI Jian Min 1,WANG Zong Min 2,YAN Zhi Qin 3,XIE Li Wei 2 Department of Neurology,1 Department of Pathology,the First Affiliated Hospital, 2 Department of Pathology,the Second Affiliated Hospital, 3 Department of Neurology,the Third Affiliated Hospital,Wenzhou Medical College,Wenzhou 325000,Zhejiang,China |
| Abstract: | AIM: To investigate the molecular mechanisms of antianxiety drugs on the rats with restraint stress. METHODS: The rat stress model was made by restraint stress. The behaviors of rats were tested in open field conditions, and the expression of c fos positive cells was detected by S P immunohistochemical assay in hypothalamus. RESULTS: The crossing scores, the rearing scores and the expression of c fos positive cells increased more significantly in the other groups than that in the control group, but decreased in the paroxetine group. The paroxetine inhibited the behaviors and the expression of c fos positive cells in the hypothalamic paraventricular nucleus (PVN) of rats after immobilization stress. CONCLUSION: The effects of paroxetine on the anxiety disorders in rats may be related to the downregulation of the expression of the c fos in the hypothalamic paraventricular nucleus (PVN). |
| Keywords: | paroxetine stress behavior c-fos hypothalamic paraventricular nucleus |
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