茶多酚对实验性动脉粥样硬化兔的血脂及炎症因子的影响

目的：探讨茶多酚（rrP）对实验性动脉粥样硬化兔的血脂、抗氧化系统及炎症因子的影响。方法：通过喂养高脂饲料建立兔的动脉粥样硬化模型，同时连续i．g．给予茶多酚（100mg·kg-1·d-1）或空白溶媒12周，测定兔血浆中TC、TG、高密度脂蛋白胆固醇（HDL．C）、低密度脂蛋白胆固醇（LDL—C）、NO、C反应蛋白（CRP）、IL-6、TNF-α含量及超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH—PX）活力，并观察主动脉病理学形态改变。结果：给予茶多酚可有效减小高脂饲料引起的兔动脉粥样硬化斑块面积，同时降低高脂血症兔血浆TG、TC、LDL．C含量（P〈0．01），增加HDL-C含量（P〈0．01）及SOD和GsH—P）（活力．而且可引起NO、CRP、IL-6、TNF-α含量下降（P〈0．01）。结论：茶多酚可以通过降低动脉粥样硬化兔血脂水平、防止脂质过氧化及抑制炎性因子的产生，从而起到抗动脉粥样硬化的作用。

Effects of tea polyphenols on the serum lipid and inflammation factor in experimental atherosclerosis rabbits

AIM: To investigate the effects of tea polyphenols (TP) on the serum lipid, the anti-oxidant system and inflammaory factor in experimental atherosclerosis (AS) rabbits. METHODS: Experimental AS model of rabbits was made by feeding high fat diet (HFD). All rabbits were treated with TP (i.g. , 100 mg·kg~(-1)·d~(-1) ) or vehicle for 12 weeks. The contents of TC, TG, HDL-C, LDL-C, NO, CRP, IL-6, TNF-α, SOD and GSH-Px in serum were measured. And the pathomorphological changes of aorta were observed. RESULTS: TP could effectively reduce the area of atherosclerotic plaques in HFD treated rabbits. It also decreased the plasma levels of TC, TG and LDL-C in hy-perlipemia rabbits( P < 0.01). At the same time, TP treatment lead to the up-regulation of plasma HDL-C levels(P < 0.01) and SOD, GSH-Px activity. Moreover , it could decrease the plasma levels of NO, CRP, IL-6 and TNF-α in HFD treated rabbits( P < 0.01). CONCLUSION: The anti-atherogenic effect of TP seems to be related to reducing serum lipids, preventing lipid hyperoxidation and inhibiting the production of inflammatory factor.