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| 超敏C-反应蛋白与高血压关系的病例对照研究 | |
| 引用本文： | 张龙,盛蕾,陈金凤,杨松,沈冲. 超敏C-反应蛋白与高血压关系的病例对照研究[J]. 中国临床药理学与治疗学, 2011, 16(10): 1164-1168 |
| 作者姓名： | 张龙 盛蕾 陈金凤 杨松 沈冲 |
| 作者单位： | 1. 南京大学医学院附属南京市鼓楼医院急诊科,南京210008,江苏 2. 江苏省第二中医院神经内科,南京210017,江苏 3. 南京医科大学公共卫生学院流行病与卫生统计学系,南京210029,江苏 4. 宜兴市人民医院心内科,宜兴214200,江苏 |
| 基金项目： | 江苏省卫生厅课题(项目号H200839); 南京医科大学校基金课题重点项目(06NMU2010) |
| 摘 要： | 目的:探讨超敏C-反应蛋白(hs-CRP)与高血压及血压水平的关系。方法:病例和对照均选自社区基础上整群调查人群;采用Logistic回归模型和分层分析方法对可能影响hs-CRP水平与高血压及血压水平关系的因素进行分析。结果:hs-CRP在高血压患者及排除药物治疗的患者和对照人群中差异均无统计学意义;但女性病例组hs-CRP水平(2.67±2.82)mg/L显著高于对照组hs-CRP水平(2.14±2.35)mg/L(t=2.1034,P=0.043)。吸烟者中校正协变量后,hs-CRP水平变化与高血压的关联有显著意义,OR(95%CI)=1.145(1.001～1.309),P=0.048;排除药物治疗的患者后关联仍有显著意义,OR(95%CI)=1.251(1.041～1.503),P=0.017;而较高hs-CRP水平(>2.4mg/L)患者高血压的患病风险也显著升高,OR 95%CI)=5.065(1.597～16.067),P=0.006。在非药物治疗患者及血压正常者中,女性SBP、DBP和平均动脉压(MAP)在hs-CRP升高组和正常组中差异均有统计学意义,而在男性中未见此差异。结论:hs-CRP水平升高是高血压的重要独立危险因素,而吸烟者患病风险更高。 |
| 关 键 词： | 高血压 超敏C-反应蛋白 病例对照研究 |
Case-control study on the relationship between high-sensitivity C-reactive protein and hypertension |
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| ZHANG Long,SHENG Lei,CHEN Jin-feng,YANG Song,SHEN Chong. Case-control study on the relationship between high-sensitivity C-reactive protein and hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(10): 1164-1168 | |
| Authors: | ZHANG Long SHENG Lei CHEN Jin-feng YANG Song SHEN Chong |
| Affiliation: | ZHANG Long1,SHENG Lei 2,CHEN Jin-feng3,YANG Song4,SHEN Chong31 Department of Emergency,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210009,Jiangsu,China,2 Department of Neurology,No.2Traditional Chinese Medicine of Jiangsu,Nanjing 210017,3 Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing 210029,4 Department of Cardiology,Yixing People's Hospital,Yixing 214200 |
| Abstract: | AIM:To investigate the correlation between high-sensitivity C-reactive protein (hs-CRP)and hypertension and blood pressure variation.METHODS:A stratified cluster sampling method was conducted to select people over the age of 40from community based population.Logistic regression and stratification analysis method were applied to evaluate the association of hs-CRP with hypertension.RESULTS:There were no statistical differences of hs-CRP between hypertensive or without medicine treatment group and control grou... |
| Keywords: | Hypertension High sensitivity-CRP Case-control study |
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