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| MC-001对大鼠脑缺血-再灌注损伤的保护作用及机制 | |
| 引用本文： | 王姗,李家明,何广卫,景蓉,吴玉林.MC-001对大鼠脑缺血-再灌注损伤的保护作用及机制[J].中国临床药理学与治疗学,2008,13(11). |
| 作者姓名： | 王姗 李家明 何广卫 景蓉 吴玉林 |
| 作者单位： | 1. 中国药科大学生理教研室,南京210009,江苏 2. 安徽中医学院药学院,合肥230031,安徽 3. 合肥医工医药有限公司,合肥230088,安徽 4. 上海交通大学药学院,上海,200030 |
| 摘 要： | 目的:研究4-O-(2’-亚甲基-3’5’6’-三甲基吡嗪基)苯甲酸(MC-001)对大鼠脑缺血-再灌注损伤的保护作用及机制。方法:采用大鼠大脑中动脉缺血-再灌注模型(cerebral ischemia-reperfusioninjury,CIRI),观察MC-001对脑缺血的影响,测定MC-001各剂量组(16、8、4 mg/kg)对脑水肿程度、组织内超氧化物歧化酶(SOD)、丙二醛(MDA)、血栓烷B2(TXB2)、6-酮-前列腺素(6-Keto-PGF1α)等生化指标的影响;采用在体动静脉血栓法,观察MC-001对血栓形成的影响。结果:MC-001(16、8 mg/kg)可显著降低脑水肿(P<0.05和P<0.01vs溶酶组),并增加CIRI大鼠脑组织SOD(P<0.05和P<0.01vs溶酶组)、降低MDA水平(P<0.05和P<0.01vs溶酶组);呈剂量依赖性地降低脑组织TXB2含量,升高6-Keto-PGF1α及6-Ke-to-PGF1α/TXB2比值(P<0.05和P<0.01vs溶酶组);显著抑制大鼠被动、静脉搭桥后形成的血栓。结论:MC-001对脑缺血-再灌注损伤有明显保护作用,其机制可能... |
| 关 键 词： | MC-001 缺血再灌注损伤 血栓 川芎嗪 |
Protective effects and the mechanism of MC-001 on focal cerebral ischemia-reperfusion rats |
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| WANG Shan,LI Jia-ming,HE Guang-wei,JING Rong,WU Yu-lin.Protective effects and the mechanism of MC-001 on focal cerebral ischemia-reperfusion rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(11). | |
| Authors: | WANG Shan LI Jia-ming HE Guang-wei JING Rong WU Yu-lin |
| Institution: | 1Department of Physiology; China Pharmaceutical University; Nanjing 210009; Jiangsu; China; 2Department of Pharmacy; Anhui College of Traditonal Chinese Medicine; Hefei 230031; Anhui; 3Hefei Yigong Medicine Company; Hefei 230088; 4Department of Pharmacy; Shanghai Jiao Tong University; Shanghai 200240; |
| Abstract: | AIM: To investigate the protective effects and the mechanism of 4-(3,5,6-trimethylpyrazin-2-yl) methoxy] benzoic acid(MC-001)on the focal cerebral ischemia-reperfusion rats.METHODS: Cerebral ischemia-reperfusion injury(CIRI) and thrombosis formation model were used to evaluate the drug s effects.After cerebral ischemia,the effect of MC-001 at different doses on cerebral edema and the biochemical indexes(SOD,MDA,TXB2,6-Keto-PGF1α) were examined.Thrombosis formation model was used to evaluate the drug s effe... |
| Keywords: | MC-001 focal cerebral ischemia-reperfusion thrombogenesis Ligustrazine |
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